Hexamethylenetetramine-based ionic liquid anchored onto the metal-organic framework MIL-101(Cr) as a superior and reusable heterogeneous catalyst for the preparation of hexahydroquinolines

Regarding the significance of medicinal and pharmacological sciences, we explored one-pot multicomponent reaction of aromatic aldehydes, aryl amines, malononitrile and dimedone in the presence of HMTA-BAIL@MIL-101 (Cr) as a novel, stable and strong catalyst. The remarkable features of this approach are good to excellent yields (92-98%), short reaction times (10-20 min), low catalyst loading, reusability and stability of the catalyst. The prepared hexamethylenetetramine-based ionic liquid/MIL-101(Cr) composite was identified via FE-SEM, XRD, EDS, TGA, BET and FT-IR techniques.

Automated summary

In this study, a novel catalyst HMTA-BAIL@MIL-101 (Cr) was used for the one-pot multicomponent reaction, leading to a composite material with good yields and stability. The prepared composite was characterized using various analytical techniques.