Potential Role of Zinc in the COVID-19 Disease Process and its Probable Impact on Reproduction

COVID-19 (coronavirus disease 2019) is the current world health crisis, producing extensive morbidity and mortality across all age groups. Given the established roles of zinc in combating oxidative damage and viral infections, zinc is being trialed as a treatment modality against COVID-19. Zinc also has confirmed roles in both male and female reproduction. The possible depletion of zinc with the oxidative events of COVID-19 is especially relevant to the fertility of affected couples. This review aims to present the pathophysiology of COVID-19, especially in relation to reproductive function; the role of zinc in the COVID-19 disease process; and how zinc depletion in concert with cytokine storm and reactive oxygen species production could affect reproduction. It also highlights research areas to better the understanding of COVID-19 and its impact on fertility and potential ways to mitigate the impact.

Automated summary

COVID-19 is a global health crisis with significant impact on morbidity and mortality, and zinc is being trialed as a potential treatment against the disease due to its roles in combating oxidative damage and viral infections. Understanding the pathophysiology of COVID-19, particularly in relation to reproductive function, and the potential effects of zinc depletion on fertility are important areas of research to better mitigate the impact of the virus.