Journal
PROGRESS IN NEUROBIOLOGY
Volume 200, Issue -, Pages -Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.pneurobio.2020.101969
Keywords
Alcohol intake; Reward; Mesolimbic dopamine system; Alcohol use disorder; Calcitonin; Amylin receptors
Categories
Funding
- Swedish Research Council [2019-01676, 2015-03219]
- LUA/ALF from the Sahlgrenska University Hospital [148251]
- Arvid Carlsson foundation
- Swedish Research Council [2019-01676] Funding Source: Swedish Research Council
Ask authors/readers for more resources
Alcohol activates reward-processing brain areas causing stimulatory behavioral responses, while sCT attenuates alcohol-mediated behaviors when infused into the laterodorsal, ventral tegmental, and nucleus accumbens regions, indicating an inhibitory effect on alcohol-induced behaviors.
Alcohol causes stimulatory behavioral responses by activating reward-processing brain areas including the laterodorsal (LDTg) and ventral tegmental areas (VTA) and the nucleus accumbens (NAc). Systemic administration of the amylin and calcitonin receptor agonist salmon calcitonin (sCT) attenuates alcohol-mediated behaviors, but the brain sites involved in this process remain unknown. Firstly, to identify potential sCT sites of action in the brain, we used immunohistochemistry after systemic administration of fluorescent-labeled sCT. We then performed behavioral experiments to explore how infused sCT into the aforementioned reward-processing brain areas affects acute alcohol-induced behaviors in mice and chronic alcohol consumption in rats. We show that peripheral sCT crosses the blood brain barrier and is detected in all the brain areas studied herein. sCT infused into the LDTg attenuates alcohol-evoked dopamine release in the NAc shell in mice and reduces alcohol intake in rats. sCT into the VTA blocks alcohol-induced locomotor stimulation and dopamine release in the NAc shell in mice and decreases alcohol intake in rats. Lastly, sCT into the NAc shell prevents alcohol-induced locomotor activity in mice. Our data suggest that central sCT modulates the ability of alcohol to activate reward-processing brain regions. .
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available