Journal
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
Volume 117, Issue 51, Pages 32701-32710Publisher
NATL ACAD SCIENCES
DOI: 10.1073/pnas.2013652117
Keywords
dopamine; in vivo neurotransmission; alpha-Synuclein
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Funding
- NIH [R01DA04718]
- JPB Foundation
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alpha-Synuclein is expressed at high levels at presynaptic terminals, but defining its role in the regulation of neurotransmission under physiologically relevant conditions has proven elusive. We report that, in vivo, alpha-synuclein is responsible for the facilitation of dopamine release triggered by action potential bursts separated by short intervals (seconds) and a depression of release with longer intervals between bursts (minutes). These forms of presynaptic plasticity appear to be independent of the presence of beta- and gamma-synucleins or effects on presynaptic calcium and are consistent with a role for synucleins in the enhancement of synaptic vesicle fusion and turnover. These results indicate that the presynaptic effects of alpha-synuclein depend on specific patterns of neuronal activity.
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