Related references
Note: Only part of the references are listed.AQP5 enriches for stem cells and cancer origins in the distal stomach
Si Hui Tan et al.
NATURE (2020)
Genome-Scale CRISPR Screening in Human Intestinal Organoids Identifies Drivers of TGF-β Resistance
Till Ringel et al.
CELL STEM CELL (2020)
Pooled In Vitro and In Vivo CRISPR-Cas9 Screening Identifies Tumor Suppressors in Human Colon Organoids
Birgitta E. Michels et al.
CELL STEM CELL (2020)
CRISPR-Cas9-mediated gene knockout in intestinal tumor organoids provides functional validation for colorectal cancer driver genes
Haruna Takeda et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2019)
Four Decades After the Discovery of Regenerating Islet-Derived (Reg) Proteins: Current Understanding and Challenges
Zijing Chen et al.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY (2019)
Genome-wide CRISPR Screens in T Helper Cells Reveal Pervasive Crosstalk between Activation and Differentiation
Johan Henriksson et al.
CELL (2019)
The biology and role of CD44 in cancer progression: therapeutic implications
Chen Chen et al.
JOURNAL OF HEMATOLOGY & ONCOLOGY (2018)
Glycogen synthase kinase 3 controls migration of the neural crest lineage in mouse and Xenopus
Sandra G. Gonzalez Malagon et al.
NATURE COMMUNICATIONS (2018)
Lgr5-expressing chief cells drive epithelial regeneration and cancer in the oxyntic stomach
Marc Leushacke et al.
NATURE CELL BIOLOGY (2017)
IncRNA Panct1 Maintains Mouse Embryonic Stem Cell Identity by Regulating TOBF1 Recruitment to Oct-Sox Sequences in Early G1
Debojyoti Chakraborty et al.
CELL REPORTS (2017)
Modeling Development and Disease with Organoids
Hans Clevers
CELL (2016)
Stomach development, stem cells and disease
Tae-Hee Kim et al.
DEVELOPMENT (2016)
Optimized sgRNA design to maximize activity and minimize off-target effects of CRISPR-Cas9
John G. Doench et al.
NATURE BIOTECHNOLOGY (2016)
Organoids as an in vitro model of human development and disease
Aliya Fatehullah et al.
NATURE CELL BIOLOGY (2016)
A CRISPR Dropout Screen Identifies Genetic Vulnerabilities and Therapeutic Targets in Acute Myeloid Leukemia
Konstantinos Tzelepis et al.
CELL REPORTS (2016)
REG3A accelerates pancreatic cancer cell growth under IL-6-associated inflammatory condition: Involvement of a REG3A-JAK2/STAT3 positive feedback loop
Xiulan Liu et al.
CANCER LETTERS (2015)
Modeling mouse and human development using organoid cultures
Meritxell Huch et al.
DEVELOPMENT (2015)
Genome-scale transcriptional activation by an engineered CRISPR-Cas9 complex
Silvana Konermann et al.
NATURE (2015)
High-throughput functional genomics using CRISPR-Cas9
Ophir Shalem et al.
NATURE REVIEWS GENETICS (2015)
Epithelial stem cells and intestinal cancer
Shawna Tan et al.
SEMINARS IN CANCER BIOLOGY (2015)
The R-spondin/Lgr5/Rnf43 module: regulator of Wnt signal strength
Wim de Lau et al.
GENES & DEVELOPMENT (2014)
Improved vectors and genome-wide libraries for CRISPR screening
Neville E. Sanjana et al.
NATURE METHODS (2014)
Genome-Scale CRISPR-Cas9 Knockout Screening in Human Cells
Ophir Shalem et al.
SCIENCE (2014)
In vitro expansion and genetic modification of gastrointestinal stem cells in spheroid culture
Hiroyuki Miyoshi et al.
NATURE PROTOCOLS (2013)
Multiplex Genome Engineering Using CRISPR/Cas Systems
Le Cong et al.
SCIENCE (2013)
clusterProfiler: an R Package for Comparing Biological Themes Among Gene Clusters
Guangchuang Yu et al.
OMICS-A JOURNAL OF INTEGRATIVE BIOLOGY (2012)
A reserve stem cell population in small intestine renders Lgr5-positive cells dispensable
Hua Tian et al.
NATURE (2011)
Lgr5+ve Stem Cells Drive Self-Renewal in the Stomach and Build Long-Lived Gastric Units In Vitro
Nick Barker et al.
CELL STEM CELL (2010)
Expression of Reg Family Proteins in Embryonic Stem Cells and Its Modulation by Wnt/β-Catenin Signaling
Donghui Jing et al.
STEM CELLS AND DEVELOPMENT (2010)
Interleukin-22 mediates early host defense against attaching and effacing bacterial pathogens
Yan Zheng et al.
NATURE MEDICINE (2008)
The double-strand RNA-dependent protein kinase PKR plays a significant role in a sustained ER stress-induced apoptosis
Eun-Soo Lee et al.
FEBS LETTERS (2007)
Identification of the transforming EML4-ALK fusion gene in non-small-cell lung cancer
Manabu Soda et al.
NATURE (2007)
Phenotypic characterization of human colorectal cancer stem cells
Piero Dalerba et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2007)
Reg I-knockout mice reveal its role in regulation of cell growth that is required in generation and maintenance of the villous structure of small intestine
T. Ose et al.
ONCOGENE (2007)
Mouse axin and Axin2/conductin proteins are functionally equivalent in vivo
IV Chia et al.
MOLECULAR AND CELLULAR BIOLOGY (2005)
Transgenic overexpression of Reg protein caused gastric cell proliferation and differentiation along parietal cell and chief cell lineages
Y Miyaoka et al.
ONCOGENE (2004)
Control of expression of the lectin-like protein Reg-1 by gastrin: role of the Rho family GTPase RhoA and a C-rich promoter element
FJ Ashcroft et al.
BIOCHEMICAL JOURNAL (2004)
Prospective identification of tumorigenic breast cancer cells
M Al-Hajj et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2003)
Proapoptotic protein PACT is expressed at high levels in colonic epithelial cells in mice
V Gupta et al.
AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY (2002)
PACT, a stress-modulated cellular activator of interferon-induced double-stranded RNA-activated protein kinase, PKR
CV Patel et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2000)