The effect of evocalcet on vagus nerve activity of the gastrointestinal tract in miniature pigs

Evocalcet is a novel calcimimetic agent with fewer gastrointestinal (GI) adverse effects compared to cinacalcet. Although it is thought that cinacalcet induces GI side effects through the direct stimulation of the calcium receptor (CaR) expressed in the GI tract, the differences in the direct stimulatory effects of these two drugs on the GI tract have not been reported. In this study, we analyzed the difference in the GI effects of these two calcimimetic agents using miniature pigs by detecting vagus nerve stimulation after oral administration of the agents. Although cinacalcet induced vomiting in miniature pigs, evocalcet never induced emetic symptoms. A significant increase in the vagus nerve action potentials was observed after the administration of cinacalcet. Although the increase of that after the administration of evocalcet was mild and not significant in comparison to that in the vehicle group, it was not significantly different from the vagus nerve action potentials after cinacalcet treatment.

Automated summary

Evocalcet, a novel calcimimetic agent, has less gastrointestinal adverse effects compared to cinacalcet. In this study using miniature pigs, it was found that cinacalcet induced vomiting while evocalcet did not, and cinacalcet significantly increased vagus nerve action potentials compared to evocalcet. However, the increase in vagus nerve action potentials after administration of evocalcet was not significantly different from that after cinacalcet treatment.