Journal
PLATELETS
Volume 33, Issue 1, Pages 89-97Publisher
TAYLOR & FRANCIS INC
DOI: 10.1080/09537104.2020.1850670
Keywords
Flow cytometry; ischemic stroke; mean platelet volume; platelet distribution width; reticulated platelets; TIA
Categories
Funding
- Meath Foundation
- Irish Institute of Clinical Neuroscience/Novartis Ireland Fellowship Grant
- Vascular Neurology Research Foundation, Ireland
- Irish Heart Foundation Stroke Prevention Bursary programme
- Biogen Idec, Ireland
- Verum Diagnostica, GmbH
- Trinity College Dublin Innovation Bursary
- Meath Foundation, Ireland
- Joint Irish Institute of Clinical Neuroscience/Merck Serono Fellowship in Neuroscience Grant
- Bayer HealthCare, Ireland
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The research found that the proportion of reticulated platelets may increase in ischemic cerebrovascular disease (CVD) patients, indicating increased platelet production and turnover, especially in patients with small vessel occlusion. These findings contribute to our understanding of the profile of reticulated platelets in CVD patients.
Information regarding the profile of reticulated platelets (RP) in ischemic cerebrovascular disease (CVD) patients is limited. Data from two prospective, observational, case-control studies were combined to compare the %RP using whole blood flow cytometry in patients <= 4 weeks of TIA/stroke onset (baseline, N = 210), and 14 +/- 7 days (14d, N = 182) and >= 90 days (90d, N = 145) after starting or changing antiplatelet therapy with healthy controls (N = 34). There were no differences in median %RP between the overall CVD patient population at baseline or 14d vs. controls (P >= 0.2). However, the median %RP was significantly higher in CVD patients overall at 90d (P = .036), and in the subgroup of patients with lacunar TIA/ischemic stroke at baseline (P = .04) and at 90d (P = .01), but not at 14d (P = .06) vs. controls. There were no significant differences in the median %RP between other TIA/stroke subgroups and controls (P >= 0.05). Elevated circulating reticulated platelets, as a marker of increased platelet production/turnover, may occur following an ischemic event in a well-phenotyped TIA/ischemic stroke population overall, but may precede symptom onset at least in the subgroup with small vessel occlusion. These data improve our understanding of the profile of reticulated platelets in CVD patients.
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