Journal
DRUG DISCOVERY TODAY
Volume 21, Issue 7, Pages 1114-1129Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.drudis.2016.04.001
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Funding
- Belgian Fonds pour la Recherche dans l'Industrie et l'Agriculture (FRIA)
- FRS-FNRS [3.4.588.10F, 3.4530.12, T.0134.13]
- Interuniversity Attraction Poles [P7/28]
- Belgian Science Policy Office
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Non-antibiotic drugs can modulate bacterial physiology and/or antibiotic activity, opening perspectives for innovative therapeutic strategies. Focusing on respiratory pathogens and considering in vitro, in vivo, and clinical data, here we examine the effect of these drugs on the expression of resistance mechanisms, biofilm formation, and intracellular survival, as well as their influence on the activity of antibiotics on bacteria. Beyond the description of the effects observed, we also comment on concentrations that are active and discuss the mechanisms of drug-drug or drug-target interactions. This discussion should be helpful in defining useful targets for adjuvant therapy and establishing the corresponding pharmacophores for further drug fine-tuning.
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