Journal
DRUG DISCOVERY TODAY
Volume 21, Issue 4, Pages 598-615Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.drudis.2015.12.003
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Funding
- National Science Centre (NCN) of Poland [UMO-2011/01/N/NZ4/01137]
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Cyclooxygenase-2 (COX-2) inhibitors are common anti-inflammatory drugs with pleiotropic, endogenous actions that could be useful in the management of breast cancer. Here, we provide a complete understanding of the biochemistry of COX-2 and discuss the various molecular mechanisms behind its increased expression in breast cancer. We also analyze the possible mechanisms responsible for the anticancer effect of COX-2 inhibitors and provide an overview of the available preclinical and clinical data on the use of COX-2 inhibitors in breast cancer. Finally, we describe a mathematical model of the relation between the structure and biological potency of promising new COX-2 inhibitors (trans-stilbenes) using a 2D quantitative structure-activity relationship (QSAR) technique.
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