Journal
DRUG DISCOVERY TODAY
Volume 21, Issue 9, Pages 1489-1494Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.drudis.2016.05.011
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Funding
- NIH [CA168464, CA203439, GM 077173]
- University of Massachusetts System President's Science and Technology Initiative Fund
- Grants-in-Aid for Scientific Research [15J07012] Funding Source: KAKEN
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Metastasis, drug resistance and recurrence in cancer are regulated by the tumor microenvironment. This review describes recent advances in understanding how cancer cells respond to extracellular environmental cues via integrins, how to build engineered microenvironments to study these interactions in vitro and how nanomaterials can be used to detect and target tumor microenvironments.
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