Journal
DRUG DISCOVERY TODAY
Volume 21, Issue 6, Pages 1009-1018Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.drudis.2016.04.009
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Funding
- National Science Center Poland [2014/15/B/ST5/04498]
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The growing resistance of pathogens to conventional antibiotics has become a public health problem and raises the need to seek new effective solutions. Metal-organic frameworks (MOFs) are porous, hybrid materials comprising metal ions linked by organic binding ligands. The possibility of using a variety of chemical building components in MOFs enables the formation of structures with desired properties. They can act as a reservoir of metal ions, providing their gradual release and resulting in a sustained antibacterial action analogous to that proposed for metal/metal oxide nanoparticles (NPs) but different to that of antibiotics. These features make MOFs promising candidates for pharmaceutical and biomedical applications, as illustrated by examples discussed in this review.
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