Journal
DRUG DISCOVERY TODAY
Volume 21, Issue 7, Pages 1063-1075Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.drudis.2016.03.001
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Funding
- Cancer Foundation Finland sr [140087] Funding Source: researchfish
- Academy of Finland (AKA) [140087] Funding Source: Academy of Finland (AKA)
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Drug discovery is moving away from the single target-based approach towards harnessing the potential of polypharmacological agents that modulate the activity of multiple nodes in the complex networks of deregulations underlying disease phenotypes. Computational network pharmacology methods that use systems-level drug-response phenotypes, such as those originating from genome-wide transcriptomic profiles, have proved particularly effective for elucidating the mechanisms of action of multitargeted compounds. Here, we show, via the case study of the natural product pinosylvin, how the combination of two complementary network-based methods can provide novel, unexpected mechanistic insights. This case study also illustrates that elucidating the mechanism of action of multitargeted natural products through transcriptional response-based approaches is a challenging endeavor, often requiring multiple computational-experimental iterations.
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