Journal
DRUG DISCOVERY TODAY
Volume 21, Issue 7, Pages 1155-1161Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.drudis.2016.05.007
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Funding
- National Natural Science Foundation of China [81373356, 81573378]
- Science and Technology Innovation Action Plan for Basic Research of Shanghai [14JC1493200]
- [CASIMM0120153020]
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The intestinal epithelium represents a barrier to the delivery of nanoparticles (NPs). It prevents intact NPs from efficiently crossing the mucosa to access the circulation, thus limiting the successful application of NP-based oral drug delivery. Recent advances in nanotechnology have provided promising solutions to this challenge. This review describes the potential intestinal absorption pathways of NPs, including the transenterocytic pathway, paracellular pathway and M-cell-mediated pathway. NP properties that influence transcytosis are summarized; and the biodistribution of NPs after oral absorption is described and the future prospects of novel NPs are explored.
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