4.5 Review

NRF2-dependent stress defense in tumor antioxidant control and immune evasion

Related references

Note: Only part of the references are listed.
Article Pharmacology & Pharmacy

Curcumin induces stabilization of Nrf2 protein through Keap1 cysteine modification

Jun Wan Shin et al.

BIOCHEMICAL PHARMACOLOGY (2020)

Review Biotechnology & Applied Microbiology

Transcription factors in ferroptotic cell death

Chongshan Dai et al.

CANCER GENE THERAPY (2020)

Review Oncology

Oxidative Stress in Cancer

John D. Hayes et al.

CANCER CELL (2020)

Article Biochemistry & Molecular Biology

Paradoxical activation of AMPK by glucose drives selective EP300 activity in colorectal cancer

Maria Gutierrez-Salmeron et al.

PLOS BIOLOGY (2020)

Article Multidisciplinary Sciences

Lymph protects metastasizing melanoma cells from ferroptosis

Jessalyn M. Ubellacker et al.

NATURE (2020)

Article Medicine, Research & Experimental

Tumor cell-intrinsic EPHA2 suppresses antitumor immunity by regulating PTGS2 (COX-2)

Nune Markosyan et al.

JOURNAL OF CLINICAL INVESTIGATION (2019)

Article Cell Biology

Lactate and pyruvate promote oxidative stress resistance through hormetic ROS signaling

Arnaud Tauffenberger et al.

CELL DEATH & DISEASE (2019)

Article Multidisciplinary Sciences

FSP1 is a glutathione-independent ferroptosis suppressor

Sebastian Doll et al.

NATURE (2019)

Article Cell Biology

Cancer-Cell-Intrinsic cGAS Expression Mediates Tumor Immunogenicity

Linda Schadt et al.

CELL REPORTS (2019)

Review Oncology

Ferroptosis at the crossroads of cancer-acquired drug resistance and immune evasion

Jose Pedro Friedmann Angeli et al.

NATURE REVIEWS CANCER (2019)

Article Biochemistry & Molecular Biology

The Autophagy Receptor Adaptor p62 is Up-regulated by UVA Radiation in Melanocytes and in Melanoma Cells

Ashley Sample et al.

PHOTOCHEMISTRY AND PHOTOBIOLOGY (2018)

Review Oncology

NRF2 and the Hallmarks of Cancer

Montserrat Rojo de la Vega et al.

CANCER CELL (2018)

Review Pharmacology & Pharmacy

Cysteine Metabolism in Neuronal Redox Homeostasis

Bindu D. Paul et al.

TRENDS IN PHARMACOLOGICAL SCIENCES (2018)

Article Oncology

Immunotherapy Resistance by Inflammation-Induced Dedifferentiation

Arnav Mehta et al.

CANCER DISCOVERY (2018)

Article Multidisciplinary Sciences

Itaconate is an anti-inflammatory metabolite that activates Nrf2 via alkylation of KEAP1

Evanna L. Mills et al.

NATURE (2018)

Article Multidisciplinary Sciences

Nrf2 negatively regulates STING indicating a link between antiviral sensing and metabolic reprogramming

David Olagnier et al.

NATURE COMMUNICATIONS (2018)

Article Multidisciplinary Sciences

A catalogue of somatic NRF2 gain-of-function mutations in cancer

Michael John Kerins et al.

SCIENTIFIC REPORTS (2018)

Article Biochemistry & Molecular Biology

ACSL4 dictates ferroptosis sensitivity by shaping cellular lipid composition

Sebastian Doll et al.

NATURE CHEMICAL BIOLOGY (2017)

Article Multidisciplinary Sciences

Dependency of a therapy-resistant state of cancer cells on a lipid peroxidase pathway

Vasanthi S. Viswanathan et al.

NATURE (2017)

Article Multidisciplinary Sciences

Dysregulated autophagy increased melanocyte sensitivity to H2O2-induced oxidative stress in vitiligo

Yuanmin He et al.

SCIENTIFIC REPORTS (2017)

Article Biochemistry & Molecular Biology

NRF2 Promotes Tumor Maintenance by Modulating mRNA Translation in Pancreatic Cancer

Iok In Christine Chio et al.

Review Genetics & Heredity

Chemical excitation of electrons: A dark path to melanoma

Sanjay Premi et al.

DNA REPAIR (2016)

Review Biochemistry & Molecular Biology

The integrated stress response

Karolina Pakos-Zebrucka et al.

EMBO REPORTS (2016)

Article Biochemistry & Molecular Biology

Photoprotection by dietary phenolics against melanogenesis induced by UVA through Nrf2-dependent antioxidant responses

Anyamanee Chaiprasongsuk et al.

REDOX BIOLOGY (2016)

Article Biochemistry & Molecular Biology

Peroxiredoxin 6 triggers melanoma cell growth by increasing arachidonic acid-dependent lipid signalling

Alexandra Schmitt et al.

BIOCHEMICAL JOURNAL (2015)

Review Biochemistry & Molecular Biology

On the role of 4-hydroxynonenal in health and disease

Miklos Csala et al.

BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE (2015)

Article Biochemistry & Molecular Biology

Cyclooxygenase-Dependent Tumor Growth through Evasion of Immunity

Santiago Zelenay et al.

Article Biochemistry & Molecular Biology

Genomic Classification of Cutaneous Melanoma

Rehan Akbani et al.

Editorial Material Dermatology

A New View of Vitiligo: Looking at Normal-Appearing Skin

Mauro Picardo et al.

JOURNAL OF INVESTIGATIVE DERMATOLOGY (2015)

Article Dermatology

MITF Modulates Therapeutic Resistance through EGFR Signaling

Zhenyu Ji et al.

JOURNAL OF INVESTIGATIVE DERMATOLOGY (2015)

Article Multidisciplinary Sciences

Oxidative stress inhibits distant metastasis by human melanoma cells

Elena Piskounova et al.

NATURE (2015)

Article Genetics & Heredity

NRF2 regulates serine biosynthesis in non-small cell lung cancer

Gina M. DeNicola et al.

NATURE GENETICS (2015)

Article Oncology

The role of thioredoxin reductase 1 in melanoma metabolism and metastasis

Pamela B. Cassidy et al.

PIGMENT CELL & MELANOMA RESEARCH (2015)

Review Biochemistry & Molecular Biology

Reactive oxygen species and mitochondria: A nexus of cellular homeostasis

Joe Dan Dunn et al.

REDOX BIOLOGY (2015)

Article Biochemistry & Molecular Biology

Regulation of Ferroptotic Cancer Cell Death by GPX4

Wan Seok Yang et al.

Review Cell Biology

Oxidative stress in melanocyte senescence and melanoma transformation

Svenja Meierjohann

EUROPEAN JOURNAL OF CELL BIOLOGY (2014)

Editorial Material Dermatology

Oxidative Stress and Vitiligo: The Nrf2-ARE Signaling Connection

Lei Qiu et al.

JOURNAL OF INVESTIGATIVE DERMATOLOGY (2014)

Article Multidisciplinary Sciences

Comprehensive molecular profiling of lung adenocarcinoma

Eric A. Collisson et al.

NATURE (2014)

Article Cell Biology

Inactivation of the ferroptosis regulator Gpx4 triggers acute renal failure in mice

Jose Pedro Friedmann Angeli et al.

NATURE CELL BIOLOGY (2014)

Article Biochemistry & Molecular Biology

Cystathionase mediates senescence evasion in melanocytes and melanoma cells

C. Leikam et al.

ONCOGENE (2014)

Article Multidisciplinary Sciences

Nrf2 Negatively Regulates Melanogenesis by Modulating PI3K/Akt Signaling

Jung-Min Shin et al.

PLOS ONE (2014)

Article Multidisciplinary Sciences

Low MITF/AXL ratio predicts early resistance to multiple targeted drugs in melanoma

Judith Mueller et al.

NATURE COMMUNICATIONS (2014)

Review Biochemistry & Molecular Biology

Hydrogen peroxide sensing, signaling and regulation of transcription factors

H. Susana Marinho et al.

REDOX BIOLOGY (2014)

Review Medicine, Research & Experimental

Targeting lactate metabolism for cancer therapeutics

Joanne R. Doherty et al.

JOURNAL OF CLINICAL INVESTIGATION (2013)

Article Multidisciplinary Sciences

Regulatory flexibility in the Nrf2-mediated stress response is conferred by conformational cycling of the Keap1-Nrf2 protein complex

Liam Baird et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2013)

Article Biotechnology & Applied Microbiology

Role of Melanin in Melanocyte Dysregulation of Reactive Oxygen Species

Noah C. Jenkins et al.

BIOMED RESEARCH INTERNATIONAL (2013)

Article Biochemistry & Molecular Biology

Ferroptosis: An Iron-Dependent Form of Nonapoptotic Cell Death

Scott J. Dixon et al.

Article Biochemistry & Molecular Biology

Nrf2 Protein Up-regulates Antiapoptotic Protein Bcl-2 and Prevents Cellular Apoptosis

Suryakant K. Niture et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2012)

Article Multidisciplinary Sciences

Melanomas resist T-cell therapy through inflammation-induced reversible dedifferentiation

Jennifer Landsberg et al.

NATURE (2012)

Article Biochemistry & Molecular Biology

Nrf2-MafG heterodimers contribute globally to antioxidant and metabolic networks

Yosuke Hirotsu et al.

NUCLEIC ACIDS RESEARCH (2012)

Article Multidisciplinary Sciences

Mechanism of Chemical Activation of Nrf2

Yun Li et al.

PLOS ONE (2012)

Article Developmental Biology

Differentiated melanocyte cell division occurs in vivo and is promoted by mutations in Mitf

Kerrie L. Taylor et al.

DEVELOPMENT (2011)

Article Multidisciplinary Sciences

Oncogene-induced Nrf2 transcription promotes ROS detoxification and tumorigenesis

Gina M. De Nicola et al.

NATURE (2011)

Article Oncology

Oncogenic NRF2 mutations in squamous cell carcinomas of oesophagus and skin

Yoo Ri Kim et al.

JOURNAL OF PATHOLOGY (2010)

Article Multidisciplinary Sciences

Keap1 perceives stress via three sensors for the endogenous signaling molecules nitric oxide, zinc, and alkenals

Michael McMahon et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2010)

Review Biochemistry & Molecular Biology

Role of Hydrogen Peroxide in NF-κB Activation: From Inducer to Modulator

Virginia Oliveira-Marques et al.

ANTIOXIDANTS & REDOX SIGNALING (2009)

Article Biochemical Research Methods

Quantitative Differential Proteome Analysis in an Animal Model for Human Melanoma

Katrin Lokaj et al.

JOURNAL OF PROTEOME RESEARCH (2009)

Article Biochemistry & Molecular Biology

Direct Interaction between Nrf2 and p21Cip1/WAF1 Upregulates the Nrf2-Mediated Antioxidant Response

Weimin Chen et al.

MOLECULAR CELL (2009)

Article Biochemistry & Molecular Biology

Heterodimerization with small Maf proteins enhances nuclear retention of Nrf2 via masking the NESzip motif

Wenge Li et al.

BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH (2008)

Article Multidisciplinary Sciences

Cancer related mutations in NRF2 impair its recognition by Keap1-Cul3 E3 ligase and promote malignancy

Tatsuhiro Shibata et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2008)

Article Biochemistry & Molecular Biology

Oxidation sensitivity of the catalytic cysteine of the protein-tyrosine phosphatases SHP-1 and SHP-2

Irene Weibrecht et al.

FREE RADICAL BIOLOGY AND MEDICINE (2007)

Article Medicine, General & Internal

Dysfunctional KEAP1-NRF2 interaction in non-small-cell lung cancer

Anju Singh et al.

PLOS MEDICINE (2006)

Article Biochemistry & Molecular Biology

Genetic evidence that small Maf proteins are essential for the activation of antioxidant response element-dependent genes

F Katsuoka et al.

MOLECULAR AND CELLULAR BIOLOGY (2005)

Article Biochemistry & Molecular Biology

The Keap1-BTB protein is an adaptor that bridges Nrf2 to a Cul3-based E3 ligase: Oxidative stress sensing by a Cul3-Keap1 ligase

SB Cullinan et al.

MOLECULAR AND CELLULAR BIOLOGY (2004)

Article Biochemistry & Molecular Biology

Oxidative stress sensor Keap1 functions as an adaptor for Cul3-based E3 ligase to regulate for proteasomal degradation of Nrf2

A Kobayashi et al.

MOLECULAR AND CELLULAR BIOLOGY (2004)

Article Biochemistry & Molecular Biology

Nrf2 is a direct PERK substrate and effector of PERK-dependent cell survival

SB Cullinan et al.

MOLECULAR AND CELLULAR BIOLOGY (2003)

Article Biochemistry & Molecular Biology

Reversible inactivation of the tumor suppressor PTEN by H2O2

SR Lee et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2002)