Journal
PHYTOTHERAPY RESEARCH
Volume 35, Issue 5, Pages 2651-2664Publisher
WILEY
DOI: 10.1002/ptr.7012
Keywords
COVID-19; molecular docking; network pharmacology; signaling pathway; Yinqiao powder
Categories
Funding
- Excellent Doctoral Dissertation Incubation Grant of First Clinical School of Guangzhou University of Chinese Medicine [YB201902]
- Excellent Doctoral Dissertation Incubation Grant of Guangzhou University of Chinese Medicine [GZYXB2020-18]
- International Program for Postgraduates, Guangzhou University of Chinese Medicine [GZYXB[2019]114]
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This study explored the active ingredients, targets, and potential mechanisms of Yinqiao powder in the treatment of COVID-19 using various methods. It confirmed the certain therapeutic effect of Yinqiao powder and provided a new perspective for discovering potential drugs and mechanisms of COVID-19.
Coronavirus disease 2019 (COVID-19) is caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). In China, Yinqiao powder is widely used to prevent and treat COVID-19 patients with Weifen syndrome. In this study, the screening and verification of active ingredients, target selection and DisGeNET scoring, drug-ingredient-gene network construction, protein-protein interaction network construction, molecular docking and surface plasmon resonance (SPR) analysis, gene ontology (GO) functional analysis, gene tissue analysis, and kyoto encyclopedia of genes and genomes (KEGG) pathway analysis were used to explore the active ingredients, targets, and potential mechanisms of Yinqiao powder in the treatment of COVID-19. We also predicted the therapeutic effect of Yinqiao powder using TCM anti-COVID-19 (TCMATCOV). Yinqiao powder has a certain therapeutic effect on COVID-19, with an intervention score of 20.16. Hesperetin, eriodictyol, luteolin, quercetin, and naringenin were the potentially effective active ingredients against COVID-19. The hub-proteins were interleukin-6 (IL-6), mitogen-activated protein kinase 3 (MAPK3), tumor necrosis factor (TNF), and tumor protein P53 (TP53). The potential mechanisms of Yinqiao powder in the treatment of COVID-19 are the TNF signaling pathway, T-cell receptor signaling pathway, Toll-like receptor signaling pathway, and MAPK signaling pathway. This study provides a new perspective for discovering potential drugs and mechanisms of COVID-19.
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