Journal
PHYTOTHERAPY RESEARCH
Volume 35, Issue 3, Pages 1468-1485Publisher
WILEY
DOI: 10.1002/ptr.6910
Keywords
apple polyphenols extract; bile acid metabolism; gut microbiota; phloretin; ulcerative colitis
Categories
Funding
- National Natural Science Foundation of China [81973023, 81673150, 81372980]
- National Key R&D Program of China [2017YFC1310700, 2017YFC1310701]
- Grant of Social Development of Suzhou [SYS201671]
- Priority Academic Program Development of Jiangsu Higher Education Institutions
Ask authors/readers for more resources
The study revealed that both apple polyphenols extract (APE) and phloretin have significant preventive effects on DSS-induced ulcerative colitis (UC), improving UC by inhibiting body weight loss, preventing colon shortening, and mucosa damage. While both APE and phloretin shared some common mechanisms in molecular pathways, they also exhibited some differences in their effects on certain bio markers.
To investigate and compare the preventive effects of apple polyphenols extract (APE) with phloretin on dextran sulfate sodium (DSS)-induced ulcerative colitis (UC), 60 male mice were treated with 125 or 500 mg/(kg bw d) APE or 100 mg/(kg bw d) phloretin, the single-ingredient of APE, for continuous 3 weeks by intragastric administration, meanwhile, mice were provided with 3% DSS dissolved in drinking water to induce UC during the third week. Both APE and phloretin significantly ameliorated DSS-induced UC by inhibiting body weight loss, preventing colon shortening and mucosa damage. Except the same mechanisms of the inhibited activation of NF-kappa B signaling, decreased hyodeoxycholic acid level and increased abundance of Verrucomicrobia at phylum and Bacteroides and Akkermansia at genus, APE increased beta-muricholic acid level and decreased Bacterodetes abundance, while phloretin decreased Firmicutes abundance. Furthermore, APE treatment showed much lower disease activity index score, less body weight loss and lighter spleen than phloretin. Thus, our study supported the potentiality of APE as a promising dietary intervention for the prevention of experimental UC.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available