Journal
DRUG DISCOVERY TODAY
Volume 21, Issue 5, Pages 819-825Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.drudis.2016.03.008
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Funding
- Medical Research Council
- MRC [MC_U105184326] Funding Source: UKRI
- Medical Research Council [MC_U105184326] Funding Source: researchfish
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In order to solve increasingly challenging protein structures with crystallography, crystallization reagents and screen formulations are regularly investigated. Here, we briefly describe 96-condition screens developed at the MRC Laboratory of Molecular Biology: the LMB sparse matrix screen, Pi incomplete factorial screens, the MORPHEUS grid screens and the ANGSTROM optimization screen. In this short review, we also discuss the difficulties and advantages associated with the development of protein crystallization screens.
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