Journal
PHYTOCHEMISTRY LETTERS
Volume 40, Issue -, Pages 63-66Publisher
ELSEVIER
DOI: 10.1016/j.phytol.2020.09.004
Keywords
Toona ciliata; B-seco Limonoids; Anti-inflammatory activities
Categories
Funding
- National Natural Science Foundation of China [31470416]
- Drug Innovation Major Project [2018ZX09711-001-007]
- National Key RAMP
- D Program of China [2018YFC1707105]
Ask authors/readers for more resources
Toonayunnanaes A-E (1-5), five B-seco limonoids, along with five known compounds (6-10) were isolated from the bark of Toona ciliata. Compound 1 is a limonoid with a epsilon-7(8)-lactone in the B ring, and compound 2 possesses a 1,14-oxygen bridge and a 15-OH. Their structures were elucidated by extensive spectroscopic analysis including 1D and 2D NMR, and HRESIMS. Compound 1 exhibited significant inhibition effect of NO production in LPS-stimulated RAW264.7 macrophages with an IC50 value of 10.94 +/- 0.08 mu M.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available
Share Paper
