Interplay of the Circadian Clock and Endothelin System

The peptide hormone endothelin-1 and its receptors are linked to several disease states. Pharmacological inhibition of this pathway has proven beneficial in pulmonary hypertension, yet its potential in other disease states remains to be realized. This review considers an often understudied aspect of endothelin biology, circadian rhythm regulation and how understanding the intersection between endothelin signaling and the circadian clock may be leveraged to realize the potential of endothelin-based therapeutics.

Automated summary

The peptide hormone endothelin-1 and its receptors are associated with various disease states, such as pulmonary hypertension. While pharmacological inhibition in pulmonary hypertension has been beneficial, further research is needed to leverage the intersection between endothelin signaling and circadian rhythm regulation for potential endothelin-based therapeutics.