Journal
PHYSICS IN MEDICINE AND BIOLOGY
Volume 66, Issue 4, Pages -Publisher
IOP Publishing Ltd
DOI: 10.1088/1361-6560/abd41a
Keywords
microwave hyperthermia; time reversal; hot-spot; multi-frequency
Funding
- VINN EXcellence Center of ChaseOn (Chalmers Antenna Systems)
- Swedish Childhood Cancer Fund
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The paper proposes a novel wideband time-reversal focusing method that iteratively shifts the focus away from hot spots and towards cold spots, improving tumor coverage and reducing the impact of hot spots. This method has been verified on different applicator topologies and target volume configurations, running within seconds.
Time-reversal (TR) is a known wideband array beam-forming technique that has been suggested as a treatment planning alternative in deep microwave hyperthermia for cancer treatment. While the aim in classic TR is to focus the energy at a specific point within the target, no assumptions are made on secondary lobes that might arise in the healthy tissues. These secondary lobes, together with tissue heterogeneity, may result in hot-spots (HSs), which are known to limit the efficiency of the thermal dose delivery to the tumor. This paper proposes a novel wideband TR focusing method that iteratively shifts the focus away from HSs and towards cold-spots from an initial TR solution, a procedure that improves tumor coverage and reduces HSs. We verify this method on two different applicator topologies and several target volume configurations. The algorithm is deterministic and runs within seconds, enabling its use for real-time applications. At the same time, it yields results comparable to those obtained with global stochastic optimizers such as Particle Swarm.
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