Journal
PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR
Volume 200, Issue -, Pages -Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.pbb.2020.173073
Keywords
BDNF; Bupropion; Depression; MDD; TNF-alpha
Ask authors/readers for more resources
This study found that bupropion SR monotherapy is effective and well tolerated in patients with moderate to severe depression, and its therapeutic efficacy is associated with an increase in serum BDNF levels and a decrease in serum TNF-alpha levels.
Background: Emerging hypotheses in the pathophysiology of major depressive disorder (MDD) indicate the role of neurotrophic factors and inflammation. This study assessed the association between therapeutic response of bupropion and serum brain-derived neurotrophic factor (BDNF) and tumour necrosis factor-alpha (TNF-alpha) levels in patients with MDD. Methods: Thirty patients (aged 18 to 60 years) with MDD diagnosed by DSM-5 criteria, with Hamilton Depression Rating scale (HAM-D) score >= 20 were included in the study. Patients were given bupropion sustained release (SR) in the doses of 150 mg once daily. All patients were followed up for 12 weeks. Results: HAM-D score at the start of the treatment was 25.57 1.85 which significantly reduced to 10.8 +/- 4.24 at 12 weeks of treatment. The serum BDNF level increased significantly (p < 0.05) from 2.42 +/- 0.19 ng/ml to 2.97 +/- 0.10 ng/ml and the levels of serum TNF-alpha reduced significantly (p < 0.05) from 4.45 +/- 0.95 pg/ml to 2.11 +/- 0.84 pg/ml at 12 weeks of treatment, in responders to treatment. Conclusion: The results of our study suggest that bupropion SR monotherapy is effective and well tolerated in MDD patients with moderate to severe depression, and its therapeutic efficacy is accompanied by an increase in serum BDNF levels and a decrease in serum TNF-alpha levels.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available