Journal
DRUG DELIVERY
Volume 23, Issue 8, Pages 3008-3016Publisher
TAYLOR & FRANCIS LTD
DOI: 10.3109/10717544.2016.1138341
Keywords
Nano-liposomes; pharmacodynamic evaluation; pharmacokinetic evaluation; prednisolone; slow-release
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A nano-liposomal carrier was prepared for the anti-inflammatory drug prednisolone acetate (PA). The drug showed remarkable loading in the nano-carriers. The drug-loaded nano-liposmes with average sizes of about 186nm and zeta potentials of - 20mV were obtained. Our drug release studies showed an apparently zero-order trend with only 18% of the drug released in the first 120 h. Fourier transform infrared (FT-IR) spectroscopy and differential scanning calorimetry (DSC) analyses showed no chemical interaction between the drug and carrier. Transmission electron microscopy (TEM) imaging showed near-spherical drug-containing nanocarriers. The intramuscular (IM) trial of the nanoformulation compared with the free drug showed both pharmacokinetic (lower C-max, higher area under the curve (AUC)) and pharmacodynamic (higher and longer lasting anti-inflammatory effect, both macroscopically and biochemically) superiority for the nano-liposomal drug above the free prednisolone in rats.
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