Journal
PHARMACOLOGICAL REVIEWS
Volume 73, Issue 1, Pages 310-520Publisher
AMER SOC PHARMACOLOGY EXPERIMENTAL THERAPEUTICS
DOI: 10.1124/pr.118.015552
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Funding
- Ministry of Defence [JFC7a/00018]
- University of Birmingham
- Celentyx Ltd.
- Centre national de la recherche scientifique (France)
- Institut national de la sante et de la recherche medicale (France)
- University of Montpellier
- Fondation pour la Recherche Medicale [DPA20140629800]
- l'Agence nationale de la recherche (France) [ANR-11-BSV4-008-01, ANR-12-BSV4-0008-01, ANR-17-CE16-0013-01, ANR-17-CE16-0010]
- France Alzheimer
- Languedoc Roussillon region
- Fondation Plan Alzheimer
- Fondation Vaincre Alzheimer [12721, FR-15072]
- National Institutes of Health National Institute on Drug Abuse [T32 DA007287, P50 DA033935, K05 DA020087]
- Banting and Best Canada Graduate Scholarship from the Canadian Institutes of Health Research
- South-Eastern Norway Regional Health Authority
- Norwegian Council on Cardiovascular Diseases
- Research Council of Norway
- Kristian Gerhard Jebsen Foundation
- Anders Jahre's Foundation for the Promotion of Science
- Family Blix foundation
- Simon Fougner Hartmann Family Foundation
- University of Oslo
- European Research Council
- Consejo Nacional de Ciencia y Tecnologia [219707]
- University of Melbourne
- Hallmark initiative
- National Health and Medical Research Council (Australia) [APP1105284, APP1105332]
- Alzheimer's Association
- Royal Australian College of General Practitioners Ltd foundation (Australia)
- Agence Nationale de la Recherche (ANR) [ANR-17-CE16-0013, ANR-17-CE16-0010, ANR-12-BSV4-0008] Funding Source: Agence Nationale de la Recherche (ANR)
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This review provides a comprehensive account of the classification and function of 5-hydroxytryptamine receptors, including how they are targeted for therapeutic benefit.
5 HT receptors expressed throughout the human body are targets for established therapeutics and various drugs in development. Their diversity of structure and function reflects the important role 5-HT receptors play in physiologic and pathophysiological processes. The present review offers a framework for the official receptor nomenclature and a detailed understanding of each of the 14 5-HT receptor subtypes, their roles in the systems of the body, and, where appropriate, the (potential) utility of therapeutics targeting these receptors. Significance Statement-This review provides a comprehensive account of the classification and function of 5-hydroxytryptamine receptors, including how they are targeted for therapeutic benefit.
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