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HY Kao et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2002)
Histone acetyltransferases: function, structure, and catalysis
R Marmorstein et al.
CURRENT OPINION IN GENETICS & DEVELOPMENT (2001)
The human histone deacetylase family
SG Gray et al.
EXPERIMENTAL CELL RESEARCH (2001)
Cloning and characterization of a novel human. Class I histone deacetylase that functions as a transcription repressor
E Hu et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2000)
Identification of a transcriptional repressor related to the noncatalytic domain of histone deacetylases 4 and 5
XB Zhou et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2000)
The language of covalent histone modifications
BD Strahl et al.
NATURE (2000)