Journal
PHARMACOLOGICAL RESEARCH
Volume 163, Issue -, Pages -Publisher
ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD
DOI: 10.1016/j.phrs.2020.105266
Keywords
Ficolins; Autoimmunity; Autoimmune diseases
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Funding
- Key Research and Development Projects of Anhui Province [1804h08020228]
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Ficolins are pattern-recognition molecules that can trigger complement activation and play a crucial role in various autoimmune diseases. Studies have elucidated the immunological regulations of ficolins and discussed their potential diagnostic and therapeutic applications in autoimmune diseases.
Ficolins are pattern-recognition molecules (PRMs) that could form complexes with mannose-binding lectin-associated serine proteases (MASPs) to trigger complement activation via the lectin pathway, thereby mediating a series of immune responses including opsonization, phagocytosis and cytokine production. In the past few decades, accumulating evidence have suggested that ficolins play a major role in the onset and development of several autoimmune diseases (ADs), including systemic lupus erythematosus (SLE), rheumatoid arthritis (RA), systemic sclerosis (SSc), Type 1 diabetes (T1D), inflammatory bowel disease (IBD), etc. In this review, we synthesized previous literatures and recent advances to elucidate the immunological regulations of ficolins and discuss the potential diagnostic ability of ficolins in ADs, as well as giving an insight into the future therapeutic options for ficolins in ADs.
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