4.4 Review

SARS-CoV-2 therapeutics: how far do we stand from a remedy?

Related references

Note: Only part of the references are listed.
Letter Gastroenterology & Hepatology

Global prediction of primary liver cancer incidences and mortality in 2040

Chenxi Li et al.

JOURNAL OF HEPATOLOGY (2023)

Article Biochemistry & Molecular Biology

SARS-CoV-2 RNA dependent RNA polymerase (RdRp) targeting: an in silico perspective

Abdo A. Elfiky

Summary: This study used molecular modeling and dynamics simulations to test the binding affinity of various clinically approved drugs and drug candidates to SARS-CoV-2 RdRp. The results showed that several drugs demonstrated effective binding, with Setrobuvir, YAK and IDX-184 showing particularly promising results.

JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS (2021)

Article Biochemistry & Molecular Biology

In-silicoapproaches to detect inhibitors of the human severe acute respiratory syndrome coronavirus envelope protein ion channel

Manoj Kumar Gupta et al.

Summary: This study investigated the structure, function, and interaction of the human SARS-CoV2 E protein with phytochemicals using computational methods. The results showed that certain phytochemicals can inhibit the protein's function, potentially serving as drugs to control diseases caused by SARS-CoV2.

JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS (2021)

Article Medicine, General & Internal

Dexamethasone in Hospitalized Patients with Covid-19

Peter Horby et al.

Summary: In patients hospitalized with Covid-19, the use of dexamethasone resulted in lower 28-day mortality among those who were receiving either invasive mechanical ventilation or oxygen alone at randomization but not among those receiving no respiratory support.

NEW ENGLAND JOURNAL OF MEDICINE (2021)

Article Biochemistry & Molecular Biology

Structure analysis of the receptor binding of 2019-nCoV

Yun Chen et al.

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2020)

Article Medicine, General & Internal

Clinical Characteristics of 138 Hospitalized Patients With 2019 Novel Coronavirus-Infected Pneumonia in Wuhan, China

Dawei Wang et al.

JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION (2020)

Review Virology

Emerging coronaviruses: Genome structure, replication, and pathogenesis

Yu Chen et al.

JOURNAL OF MEDICAL VIROLOGY (2020)

Article Medicine, General & Internal

Clinical features of patients infected with 2019 novel coronavirus in Wuhan, China

Chaolin Huang et al.

LANCET (2020)

Article Medicine, General & Internal

First Case of 2019 Novel Coronavirus in the United States

Michelle L. Holshue et al.

NEW ENGLAND JOURNAL OF MEDICINE (2020)

Article Medicine, General & Internal

Early Transmission Dynamics in Wuhan, China, of Novel Coronavirus-Infected Pneumonia

Qun Li et al.

NEW ENGLAND JOURNAL OF MEDICINE (2020)

Article Virology

Return of the Coronavirus: 2019-nCoV

Lisa E. Gralinski et al.

VIRUSES-BASEL (2020)

Article Pharmacology & Pharmacy

Analysis of therapeutic targets for SARS-CoV-2 and discovery of potential drugs by computational methods

Canrong Wu et al.

ACTA PHARMACEUTICA SINICA B (2020)

Editorial Material Public, Environmental & Occupational Health

Ivermectin and COVID-19: Keeping Rigor in Times of Urgency

Carlos Chaccour et al.

AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE (2020)

Article Medicine, Research & Experimental

Probable Molecular Mechanism of Remdesivir for the Treatment of COVID-19: Need to Know More

Abinit Saha et al.

ARCHIVES OF MEDICAL RESEARCH (2020)

Editorial Material Medicine, Research & Experimental

Tocilizumab: A Therapeutic Option for the Treatment of Cytokine Storm Syndrome in COVID-19

Abinit Saha et al.

ARCHIVES OF MEDICAL RESEARCH (2020)

Editorial Material Medicine, Research & Experimental

Extensive Partnership, Collaboration, and Teamwork is Required to Stop the COVID-19 Outbreak

Chiranjib Chakraborty et al.

ARCHIVES OF MEDICAL RESEARCH (2020)

Review Medicine, Research & Experimental

Structural Proteins in Severe Acute Respiratory Syndrome Coronavirus-2

Sairaj Satarker et al.

ARCHIVES OF MEDICAL RESEARCH (2020)

Article Infectious Diseases

Hydroxychloroquine and azithromycin as a treatment of COVID-19: results of an open-label non-randomized clinical trial

Philippe Gautret et al.

INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS (2020)

Article Multidisciplinary Sciences

Effective treatment of severe COVID-19 patients with tocilizumab

Xiaoling Xu et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2020)

Article Medicine, General & Internal

Remdesivir for the Treatment of Covid-19-Final Report

John H. Beigel et al.

NEW ENGLAND JOURNAL OF MEDICINE (2020)

Article Medicine, General & Internal

A Trial of Lopinavir-Ritonavir in Adults Hospitalized with Severe Covid-19

B. Cao et al.

NEW ENGLAND JOURNAL OF MEDICINE (2020)

Article Medicine, General & Internal

Compassionate Use of Remdesivir for Patients with Severe Covid-19

J. Grein et al.

NEW ENGLAND JOURNAL OF MEDICINE (2020)

Letter Gastroenterology & Hepatology

Prolonged presence of SARS-CoV-2 viral RNA in faecal samples

Yongjian Wu et al.

LANCET GASTROENTEROLOGY & HEPATOLOGY (2020)

Article Pharmacology & Pharmacy

Remdesivir and SARS-CoV-2: Structural requirements at both nsp12 RdRp and nsp14 Exonuclease active-sites

Ashleigh Shannon et al.

ANTIVIRAL RESEARCH (2020)

Article Pharmacology & Pharmacy

The FDA-approved drug ivermectin inhibits the replication of SARS-CoV-2 in vitro

Leon Caly et al.

ANTIVIRAL RESEARCH (2020)

Article Multidisciplinary Sciences

Syrian hamsters as a small animal model for SARS-CoV-2 infection and countermeasure development

Masaki Imai et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2020)

Review Virology

COVID-19 Vaccine: A comprehensive status report

Simran Preet Kaur et al.

VIRUS RESEARCH (2020)

Article Medicine, General & Internal

Association Between Administration of Systemic Corticosteroids and Mortality Among Critically Ill Patients With COVID-19 A Meta-analysis

Jonathan A. C. Sterne et al.

JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION (2020)

Review Medicine, Research & Experimental

The immune system as a target for therapy of SARS-CoV-2: A systematic review of the current immunotherapies for COVID-19

Amir Hossein Mansourabadi et al.

LIFE SCIENCES (2020)

Article Pharmacology & Pharmacy

Dual-histamine receptor blockade with cetirizine - famotidine reduces pulmonary symptoms in COVID-19 patients

Reed B. Hogan et al.

PULMONARY PHARMACOLOGY & THERAPEUTICS (2020)

Article Genetics & Heredity

Genomic characterization of a novel SARS-CoV-2

Rozhgar A. Khailany et al.

GENE REPORTS (2020)

Review Medicine, General & Internal

Convalescent plasma or hyperimmune immunoglobulin for people with COVID-19: a living systematic review

Vanessa Piechotta et al.

COCHRANE DATABASE OF SYSTEMATIC REVIEWS (2020)

Article Biochemistry & Molecular Biology

Predicting commercially available antiviral drugs that may act on the novel coronavirus (SARS-CoV-2) through a drug-target interaction deep learning model

Bo Ram Beck et al.

COMPUTATIONAL AND STRUCTURAL BIOTECHNOLOGY JOURNAL (2020)

Article Gastroenterology & Hepatology

Efficacy and Safety of 12-week Interferon-based Danoprevir Regimen in Patients with Genotype 1 Chronic Hepatitis C

Lai Wei et al.

JOURNAL OF CLINICAL AND TRANSLATIONAL HEPATOLOGY (2019)

Review Biotechnology & Applied Microbiology

Drug repurposing: progress, challenges and recommendations

Sudeep Pushpakom et al.

NATURE REVIEWS DRUG DISCOVERY (2019)

Article Peripheral Vascular Disease

Understanding Angiotensin II Type 1 Receptor Signaling in Vascular Pathophysiology

Satoru Eguchi et al.

HYPERTENSION (2018)

Article Multidisciplinary Sciences

The mechanism of resistance to favipiravir in influenza

Daniel H. Goldhill et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2018)

Review Multidisciplinary Sciences

Favipiravir (T-705), a broad spectrum inhibitor of viral RNA polymerase

Yousuke Furuta et al.

PROCEEDINGS OF THE JAPAN ACADEMY SERIES B-PHYSICAL AND BIOLOGICAL SCIENCES (2017)

Article Cell Biology

Broad-spectrum antiviral GS-5734 inhibits both epidemic and zoonotic coronaviruses

Timothy P. Sheahan et al.

SCIENCE TRANSLATIONAL MEDICINE (2017)

Review Pharmacology & Pharmacy

Targeting endosomal acidification by chloroquine analogs as a promising strategy for the treatment of emerging viral diseases

Md Abdul Alim Al-Bari

PHARMACOLOGY RESEARCH & PERSPECTIVES (2017)

Review Infectious Diseases

A review of treatment modalities for Middle East Respiratory Syndrome

Yin Mo et al.

JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY (2016)

Article Economics

Innovation in the pharmaceutical industry: New estimates of R&D costs

Joseph A. DiMasi et al.

JOURNAL OF HEALTH ECONOMICS (2016)

Review Microbiology

SARS and MERS: recent insights into emerging coronaviruses

Emmie de Wit et al.

NATURE REVIEWS MICROBIOLOGY (2016)

Review Pharmacology & Pharmacy

SARS-CoV ORF1b-encoded nonstructural proteins 12-16: Replicative enzymes as antiviral targets

Lorenzo Subissi et al.

ANTIVIRAL RESEARCH (2014)

Review Pharmacology & Pharmacy

Arbidol as a broad-spectrum antiviral: An update

Julie Blaising et al.

ANTIVIRAL RESEARCH (2014)

Article Multidisciplinary Sciences

RNA 3′-end mismatch excision by the severe acute respiratory syndrome coronavirus nonstructural protein nsp10/nsp14 exoribonuclease complex

Mickael Bouvet et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2012)

Article Microbiology

In Vitro Reconstitution of SARS-Coronavirus mRNA Cap Methylation

Mickael Bouvet et al.

PLOS PATHOGENS (2010)

Article Multidisciplinary Sciences

Functional screen reveals SARS coronavirus nonstructural protein nsp14 as a novel cap N7 methyltransferase

Yu Chen et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2009)

Article Microbiology

Preclinical Characteristics of the Hepatitis C Virus NS3/4A Protease Inhibitor ITMN-191 (R7227)

Scott D. Seiwert et al.

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY (2008)

Review Allergy

History of Immunoglobulin Replacement

Martha M. Eibl

IMMUNOLOGY AND ALLERGY CLINICS OF NORTH AMERICA (2008)

Article Biochemistry & Molecular Biology

A second, non-canonical RNA-dependent RNA polymerase in SARS coronavirus

Isabelle Imbert et al.

EMBO JOURNAL (2006)

Article Multidisciplinary Sciences

Severe acute respiratory syndrome coronavirus nsp1 protein suppresses host gene expression by promoting host mRNA degradation

Wataru Kamitani et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2006)

Review Biotechnology & Applied Microbiology

Sildenafil: from angina to erectile dysfunction to pulmonary hypertension and beyond

Hossein A. Ghofrani et al.

NATURE REVIEWS DRUG DISCOVERY (2006)

Review Virology

Mechanisms of action of ribavirin against distinct viruses

JD Graci et al.

REVIEWS IN MEDICAL VIROLOGY (2006)

Article Biochemistry & Molecular Biology

Insights into SARS-CoV transcription and replication from the structure of the nsp7-nsp8 hexadecamer

YJ Zhai et al.

NATURE STRUCTURAL & MOLECULAR BIOLOGY (2005)

Review Medicine, General & Internal

Antiinflammatory action of glucocorticoids - New mechanisms for old drugs

T Rhen et al.

NEW ENGLAND JOURNAL OF MEDICINE (2005)

Article Biochemistry & Molecular Biology

Design of wide-spectrum inhibitors targeting coronavirus main proteases

HT Yang et al.

PLOS BIOLOGY (2005)

Article Biochemistry & Molecular Biology

A crucial role of angiotensin converting enzyme 2 (ACE2) in SARS coronavirus-induced lung injury

K Kuba et al.

NATURE MEDICINE (2005)

Article Immunology

Plasma inflammatory cytokines and chemokines in severe acute respiratory syndrome

CK Wong et al.

CLINICAL AND EXPERIMENTAL IMMUNOLOGY (2004)

Article Biochemistry & Molecular Biology

The nsp9 replicase protein of SARS-coronavirus, structure and functional insights

G Sutton et al.

STRUCTURE (2004)

Article Multidisciplinary Sciences

Major genetic marker of nidoviruses encodes a replicative endoribonuclease

KA Ivanov et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2004)

Article Biochemistry & Molecular Biology

Structure of the N-terminal RNA-binding domain of the SARS CoV nucleocapsid protein

QL Huang et al.

BIOCHEMISTRY (2004)

Article Biotechnology & Applied Microbiology

Mechanisms and enzymes involved in SARS coronavirus genome expression

V Thiel et al.

JOURNAL OF GENERAL VIROLOGY (2003)

Article Multidisciplinary Sciences

RNA virus error catastrophe: Direct molecular test by using ribavirin

S Crotty et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2001)

Review Multidisciplinary Sciences

Intracellular functions of N-linked glycans

A Helenius et al.

SCIENCE (2001)

Review Biotechnology & Applied Microbiology

Virus-encoded proteinases and proteolytic processing in the Nidovirales

J Ziebuhr et al.

JOURNAL OF GENERAL VIROLOGY (2000)