Journal
PERIODICA POLYTECHNICA-CHEMICAL ENGINEERING
Volume 65, Issue 2, Pages 183-191Publisher
BUDAPEST UNIV TECHNOLOGY ECONOMICS
DOI: 10.3311/PPch.16869
Keywords
polyaspartamides; rheology; hydrolytic stability; degradation
Categories
Funding
- National Research Development and Innovation (NRDI) Fund [TKP2020 IES, BME-IE-BIO]
- Ministry for Innovation and Technology, Hungary [FK 125074]
- NRDI Office [FK 125074]
- Hungarian Academy of Sciences [UNKP-19-4-BME-421]
- Stipendium Hungaricum
Ask authors/readers for more resources
Thiolated polyaspartamides with different side groups were synthesized and their hydrolytic stability was studied. DME side groups led to main-chain degradation, while DMP or HE side groups showed considerable stability. The structure-dependent aqueous degradation of polyaspartamides can be useful in various biomedical fields.
Thiolated polyaspartamides either with N,N-dimethyl-2-aminoethyl (DME), N,N-dimethyl-3-aminopropyl (DMP) or 2-hydroxyethyl (HE) side groups were synthesized to study the effect of side groups on the hydrolytic stability of these polymers. The chemical structure of linear polymers was confirmed by 'H NMR spectroscopy, while thiol content was determined by Ellman's assay. Hydrolytic stability of thiolated polyaspartamides was studied by viscosity measurements and results suggested main-chain degradation in the presence of DME side groups. Polyaspartamides with DMP or HE side groups showed considerable stability. Thiolated polyaspartamides were converted to their disulfide cross-linked hydrogels and the gelation process was followed by oscillatory rheology. Time-dependence of dynamic moduli indicated the degradation of hydrogels containing DME side groups, while stable moduli were observed for hydrogels containing DMP or HE side groups. This structure-dependent aqueous degradation of polyaspartamides can be useful in different biomedical fields.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available