Journal
ORGANIC LETTERS
Volume 23, Issue 2, Pages 262-267Publisher
AMER CHEMICAL SOC
DOI: 10.1021/acs.orglett.0c03460
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Funding
- National Natural Science Foundation of China [31770392, 31730037, 31900737]
- Strategic Priority Research Program (B) of CAS [XDB02020003]
- Project for International Collaboration of the Bureau of International Collaboration, CAS [GJHZ1846]
- CAS [ZDBS-LY-SM031]
- Science and Technology Program of Yunnan Province [2018ZF013]
- CAS Light of West China Program [2020000023]
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Harpertrioate A, isolated from the twigs of Harrisonia perforata, showed biological activities against Alzheimer's disease by reducing the production of Aβ42 and Aβ40 and shifting the APP processing towards a nonamyloidogenic pathway. Its effect on Aβ production was comparable to that of gemfibrozil.
Harpertrioate A (1), an A, B,D-seco-limonoid with a rearranged ring B incorporating exocyclic C-30, was isolated from the EtOAc extract of Harrisonia perforata twigs. Its structure, including absolute configurations, was determined on the basis of spectroscopic data and X-ray crystallography. This compound exhibited biological activities against Alzheimer's disease by reducing A beta 42 and A beta 40 production and shifting APP processing toward nonamyloidogenic pathway. The effect of 1 on the A beta production was comparable to that of gemfibrozil.
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