Journal
ORGANIC LETTERS
Volume 23, Issue 3, Pages 762-766Publisher
AMER CHEMICAL SOC
DOI: 10.1021/acs.orglett.0c03991
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Funding
- National Natural Science Foundation of China [81821004, 21871011, U1604285, 21877206]
- 111 Project [D17007]
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Described here is a Cu-catalyzed [2 + 2 + 1] modular synthesis of full-substituted beta-pyrrolinones from simple amines, alkynes, and alpha-diazo-beta-ketoesters. This approach enables the direct synthesis of full-substituted beta-pyrrolinones, which were hardly constructed by traditional synthetic strategies.
Described here is a Cu-catalyzed [2 + 2 + 1] modular synthesis of full-substituted beta-pyrrolinones from simple amines, alkynes, and alpha-diazo-beta-ketoesters. This approach involving the regioselective C-nucleophilic attack of enamines, uncommon C-nucleophilic addition to ketenes, and umpolung of imines enables the direct synthesis of full-substituted beta-pyrrolinones, which were hardly constructed by traditional synthetic strategies.
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