Journal
ORGANIC LETTERS
Volume 22, Issue 24, Pages 9524-9528Publisher
AMER CHEMICAL SOC
DOI: 10.1021/acs.orglett.0c03581
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Funding
- NSF [CHE176429, 1S10RR023444, 1S10RR022442, CHE-0840438, CHE-0848460, 1S10OD011980, CHE-1827457]
- NIH [R35 GM131902]
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We describe herein a Cu(OTf)(2) catalyzed oxidative arylation of a tertiary carbon-containing substrate including aryl malononitriles, 3-aryl benzofuran-2-ones, and 3-aryl oxindoles. In some cases, the nitrile groups of the aryl malononitriles undergo further reactions leading to lactones or imines. These reaction conditions are applicable for a range of arenes, including phenols, anilines, anisoles, and heteroarenes. Mechanistic studies support the formation of a cationic intermediate via a two-electron oxidation.
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