Journal
ORGANIC LETTERS
Volume 22, Issue 24, Pages 9609-9613Publisher
AMER CHEMICAL SOC
DOI: 10.1021/acs.orglett.0c03660
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Funding
- NSFC [21772208]
- Key Research Program of Frontier Sciences of CAS [QYZDJSSW-SLH051]
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A Ni-catalyzed aryl C-N bond cleavage of monoprotected anilines, N-arylsulfonamides, has been developed. A new N-heterocyclic carbene derived from benzoimidazole shows high reactivity for the C-N cleavage/C-C cross-coupling reaction. The ortho-directing group is not required to break the C-N bond of sulfonyl-protected anilines, which are not limited to p-extended anilines. The mechanistic studies have revealed that a sulfamidomagnesium salt is the key coupling intermediate.
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