Journal
ORGANIC LETTERS
Volume 23, Issue 1, Pages 190-194Publisher
AMER CHEMICAL SOC
DOI: 10.1021/acs.orglett.0c03915
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Funding
- NIH Common Fund [U01GM125274]
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This study introduces a new convenient method for the photocatalytic generation of glycosyl fluorides using sulfur(VI) hexafluoride and 4,4'-dimethoxybenzophenone. The mild method is able to generate 16 different glycosyl fluorides with yields ranging from 43% to 97% and can be applied on a large scale with high yield in continuous flow synthesis.
This study describes a new convenient method for the photocatalytic generation of glycosyl fluorides using sulfur(VI) hexafluoride as an inexpensive and safe fluorinating agent and 4,4'-dimethoxybenzophenone as a readily available organic photocatalyst. This mild method was employed to generate 16 different glycosyl fluorides, including the substrates with acid and base labile functionalities, in yields of 43%-97%, and it was applied in continuous flow to accomplish fluorination on an 7.7 g scale and 93% yield.
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