Synthesis of (E)-Quinoxalinone Oximes through a Multicomponent Reaction under Mild Conditions

Herein, a novel method for the gram-scale synthesis of (E)-quinoxalinone oximes through a multicomponent reaction under mild conditions is described. Such a transformation was performed under transition-metal-free conditions, affording (E)-oximes in a moderate-to-good yield through recrystallization. Our methodology demonstrates a successful combination of a Mannich-type reaction and radical coupling, providing a green and practical approach for the synthesis of potentially bioactive quinoxalinone-containing molecules.

Automated summary

This research presents a novel method for synthesizing (E)-quinoxalinone oximes through a multicomponent reaction under mild conditions, yielding moderate-to-good results. The combination of Mannich-type reaction and radical coupling in this methodology offers a green and practical approach for the synthesis of potentially bioactive quinoxalinone-containing molecules.