Journal
ORGANIC LETTERS
Volume 23, Issue 5, Pages 1525-1529Publisher
AMER CHEMICAL SOC
DOI: 10.1021/acs.orglett.0c03996
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Funding
- National Key R&D Program of China [2018YFC0311000]
- National Natural Science Foundation of China [81673331]
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Genome mining of Aspergillus ustus 094102 led to the discovery of a multiproduct bifunctional terpene synthase (BTS), AuAS, which produced five new sesterterpenes when heterologously expressed. Coexpression with the CYP450 monooxygenase (AuAP450) generated four new sesterterpene alcohols. Additionally, two of the synthesized compounds, aspergilol A and aspergilol B, exhibited cytotoxic effects on cancer cells.
Genome mining of Aspergillus ustus 094102 enabled the discovery of a multiproduct bifunctional terpene synthase (BTS), AuAS. Heterologous expression of AuAS led to the discovery of five new sesterterpenes, and coexpression of the upstream CYP450 monooxygenase (AuAP450) generated four new sesterterpene alcohols. Additionally, aspergilol A showed cytotoxic activities against MCF-7, MDA-MB231, and HepG2 cancer cells (IC50 21.20-48.76 mu M), and aspergilol B exhibited a cytotoxic effect on MCF-7 cells (IC50 27.41 mu M).
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