Journal
ORGANIC LETTERS
Volume 23, Issue 3, Pages 858-862Publisher
AMER CHEMICAL SOC
DOI: 10.1021/acs.orglett.0c04092
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Funding
- National Natural Science Foundation of China [21602047]
- Foundation of Henan Province for Science and Teachers of Colleges and Universities [2017GGJS-081]
- Key Projects for Science and Technology Development of Henan [202102310509]
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Three tetrahydroquinoline alkaloids with a unique structure were isolated from the fruits of Lycium barbarum, and compounds 1 and 3 showed neuroprotective activity by inhibiting apoptosis in PC12 cells.
Three tetrahydroquinoline alkaloids, lycibarbarines A-C (1-3), possessing a unique tetracyclic tetrahydroquinoline-oxazine-ketohexoside fused motif, were isolated from the fruits of Lycium barbarum. Their structures were determined by spectroscopic analysis and quantum-chemical calculations. Compounds 1 and 3 exhibited neuroprotective activity when evaluated for corticosterone-induced injury by reducing the apoptosis of PC12 cells through the inhibition of caspase-3 and caspase-9.
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