Asymmetric α-Hydroxylation of α-Aryl-δ-lactams with Molecular Oxygen under Phase-Transfer Conditions

An asymmetric synthesis of alpha-aryl-alpha-hydroxy-delta-lactams via phase-transfer-catalyzed hydroxylation with molecular oxygen is described. High yields and high enantioselectivities were achieved using 2,2-diarylvinyl group as an achiral auxiliary. This strategy allows facile access to alpha-aryl-alpha-hydroxy-delta-lactam derivatives containing a chiral quaternary center.

Automated summary

An asymmetric synthesis of alpha-aryl-alpha-hydroxy-delta-lactams via phase-transfer-catalyzed hydroxylation with molecular oxygen is described. High yields and high enantioselectivities were achieved using 2,2-diarylvinyl group as an achiral auxiliary, facilitating access to alpha-aryl-alpha-hydroxy-delta-lactam derivatives containing a chiral quaternary center.