Journal
ORGANIC LETTERS
Volume 23, Issue 3, Pages 797-801Publisher
AMER CHEMICAL SOC
DOI: 10.1021/acs.orglett.0c04024
Keywords
-
Categories
Funding
- NIH-NIGMS [R01GM101389]
- NIH [S10 OD021758-01A1]
Ask authors/readers for more resources
Enolizable cyclic imines obtained in situ from lithium amides by oxidation with simple ketone oxidants can be readily alkylated with a range of enolates to provide mono- and polycyclic beta-aminoketones in a single operation, including the natural product (+/-)-myrtine. Nitrile anions also serve as competent nucleophiles in these transformations promoted by BF3 etherate. Moreover, beta-aminoesters derived from ester enolates can be converted to the corresponding beta-lactams.
Enolizable cyclic imines, obtained in situ from their corresponding lithium amides by oxidation with simple ketone oxidants, are readily alkylated with a range of enolates to provide mono- and polycyclic beta-aminoketones in a single operation, including the natural product (+/-)-myrtine. Nitrile anions also serve as competent nucleophiles in these transformations, which are promoted by BF3 etherate. beta-Aminoesters derived from ester enolates can be converted to the corresponding beta-lactams.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available
Share Paper
