Journal
ORGANIC LETTERS
Volume 23, Issue 3, Pages 1000-1004Publisher
AMER CHEMICAL SOC
DOI: 10.1021/acs.orglett.0c04203
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Funding
- Natural Science Foundation of China [21901100, 21625203]
- Jiangxi Province Science and Technology Project [20202ACBL216017, 20182BCB22007]
- Jiangxi Provincial Graduate Innovation Special Fund [YC2019008]
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A new radical-mediated decarboxylative C(sp(3))-N cross-coupling reaction has been disclosed, involving diacyl peroxides reacting with nitrogen nucleophiles. The alkyl radicals derived from diacyl peroxides were generated through copper catalysis or through a combination of copper catalysis and photoredox catalysis. Various N-alkyl nitrogen nucleophiles showed a broad substrate scope and good functional group tolerance.
We have disclosed a new radical-mediated decarboxylative C(sp(3))-N cross-coupling of diacyl peroxides with nitrogen nucleophiles. The primary and secondary alkyl radicals derived from corresponding diacyl peroxides were generated by copper catalysis or by merging copper catalysis and photoredox catalysis, respectively. Various N-alkyl nitrogen nucleophiles, including indazoles, triazoles, indoles, purine, carbazole, anilines, and sulfonamide, were provided with a broad substrate scope and good functional group tolerance.
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