Journal
OPTICS LETTERS
Volume 46, Issue 2, Pages 262-265Publisher
OPTICAL SOC AMER
DOI: 10.1364/OL.412993
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Funding
- Japan Society of Applied Physics [JP18K14149, JP19KK0379, JP20J12903]
- Core Research for Evolutional Science and Technology [JPMJCR20T4]
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By controlling the ratio of two blended polymers, the surface charge of the microdisk could be modulated to affect the non-specific adsorption of biomolecules. This study demonstrated the potential value of blended polymer microdisk lasers in biosensing applications.
A blended FC-V-50 and TZ-001 polymer-based microdisk laser was fabricated by the ink-jet printing method and. used for biosensing applications. The FC-V-50 polymer has a negative charge due to the presence of carboxyl functional groups, and the TZ-001 polymer has a positive charge due to the tertiary amine group at a pH of seven. In biosensing applications, non-specific adsorption due to opposite charges of biomolecules and microdisk surfaces can adversely affect the performance of the biosensor. By mixing FC-V-50 and TZ-001 polymers in different ratios, the microdisk surface charge was controlled, and the non-specific adsorption of bovine serum albumin and lysozyme was studied. In addition, the label-free biosensing of streptavidin was demonstrated using a blended polymerbased microdisk laser. This work reports, to the best of our knowledge, the first demonstration of a blended polymer microdisk laser for controlling the non-specific adsorption of biomolecules. (C) 2021 Optical Society of America
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