Journal
OPHTHALMOLOGICA
Volume 244, Issue 2, Pages 133-140Publisher
KARGER
DOI: 10.1159/000513080
Keywords
Retinal detachment; Risk factor analysis; Gutenberg Health Study; Population-based cohort study; Epidemiology
Categories
Funding
- government of Rhineland-Palatinate (Stiftung Rheinland-Pfalz fur Innovation) [AZ 961-386261/733]
- Center for Translational Vascular Biology (CTVB) of the Johannes Gutenberg University of Mainz
- Boehringer Ingelheim
- Philips Medical Systems [BMBF 01EO1503]
- Federal Ministry of Education and Research [BMBF 01EO1503]
- German Center for Cardiovascular Research (DZHK)
- Novartis
- Ivantis
- Santen
- Thea
- Boehringer Ingelheim Deutschland GmbH and Co. KG
- Alcon
- Sanoculis
- government of Rhineland-Palatinate
- government of NordrheinWestfalen
- German Association of Psychoanalysis and Psychotherapy (DGPT)
- German Research Foundation
- German Ministry of Research
- German Cancer Aid
- European Union
- Deutsche Ophthalmologische Gesellschaft
- Berufsverband der Augenarzte Deutschland e.V.
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The study investigated the incidence of retinal detachment in the German population, finding it comparable to estimates from neighboring European countries for individuals aged 35-74 years. Risk factors identified were male sex, pseudophakia, and myopia.
Purpose: To investigate the incidence of retinal detachment in the German population and to assess potential risk factors. Methods: The Gutenberg Health Study is a population-based cohort study in Mainz, Germany, including subjects (n = 15,010) with an age range from 35 to 74 years at baseline examination. Study participants underwent a comprehensive ophthalmological examination including distant-corrected visual acuity, refraction and slit-lamp examination at baseline examination. A computer-assisted telephone interview was conducted after 2.5 and 5 years, and health events were recorded. The 5-year cumulative incidence of retinal detachment was computed for the study sample and stratified on age decades. Risk factors were analyzed using logistic regression including age, sex, spherical equivalent, pseudophakia and prior laser retinal therapy. Results: 13,416 participants (age 52.2 +/- 10.7 years, 48.8% female) were included in this analysis. Twenty-eight subjects had a retinal detachment in one eye, no subject had a retinal detachment in both eyes. The 5-year cumulative incidence of retinal detachment was 0.21% (95% CI 0.14-0.31%), the incidence rate was 42/100,000 person-years. Risk factors were male sex (OR 4.16, p = 0.004), pseudophakia (OR 3.93, p = 0.045) and myopia (OR 1.31 per diopter myopia, p < 0.0001), but not prior retinal laser therapy or age. Conclusion: The incidence of retinal detachment in Germany at the age of 35-74 years is comparable to estimates from neighboring European countries. Risk factors are male sex, pseudophakia and myopia.
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