Journal
ONCOLOGY REPORTS
Volume 45, Issue 3, Pages 824-834Publisher
SPANDIDOS PUBL LTD
DOI: 10.3892/or.2021.7927
Keywords
epidermal growth factor receptor pathway substrate 8; malignant tumours; proliferation; migration; invasion
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Funding
- National Natural Science Foundation of China [81860463]
- Science and Technology Department of Yunnan Province
- Kunming Medical University Project Foundation [2018FE001(-003), 2017FE468(-067)]
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Eps8, overexpressed in most malignant tumors, plays a crucial role in regulating malignant phenotypes and is associated with patient prognosis, making it a potential biomarker for tumor diagnosis and prognosis. Its potential as a therapeutic target for cancer therapy is also explored.
Epidermal growth factor receptor pathway substrate 8 (Eps8) was initially identified as the substrate for the kinase activity of EGFR, improving the responsiveness of EGF, which is involved in cell mitosis, differentiation and other physiological functions. Numerous studies over the last decade have demonstrated that Eps8 is overexpressed in most ubiquitous malignant tumours and subsequently binds with its receptor to activate multiple signalling pathways. Eps8 not only participates in the regulation of malignant phenotypes, such as tumour proliferation, invasion, metastasis and drug resistance, but is also related to the clinicopathological characteristics and prognosis of patients. Therefore, Eps8 is a potential tumour diagnosis and prognostic biomarker and even a therapeutic target. This review aimed to describe the structural characteristics, role and related molecular mechanism of Eps8 in malignant tumours. In addition, the prospect of Eps8 as a target for cancer therapy is examined.
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