4.5 Article

Evaluation of muscle-skeletal strength and peak expiratory flow in severely malnourished inpatients with anorexia nervosa: A pilot study

Journal

NUTRITION
Volume 85, Issue -, Pages -

Publisher

ELSEVIER SCIENCE INC
DOI: 10.1016/j.nut.2020.111133

Keywords

Anorexia nervosa; Malnutrition; Muscle strength; MMT; PEF

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This study examined muscle strength and peak expiratory flow (PEF) in severely undernourished patients with anorexia nervosa at admission and after 5 weeks of refeeding through tube feeding. Results showed a significant association between severity of undernourishment and muscle weakness, with partial recovery observed after enteral nutrition.
Objectives: Anorexia nervosa is a complex psychiatric disorder that can lead to specific somatic complications. Malnutrition is frequent and can involve a decrease of mobility, up to functional impotence, in individuals with extremely severe cases. The aim of this pilot study was to examine muscle strength and peak expiratory flow (PEF) in severely undernourished patients with anorexia nervosa at admission and after 5 wk of renutrition by tube feeding, and to find the clinical and biological correlates of muscle-strength impairment. Methods: A prospective observational study was conducted over 6 mo. Manual muscle testing, measures of PEF, and clinical and biologic assessments were performed at baseline and after 5 wk of renutrition. Results: Twenty-three extremely malnourished female participants (mean body mass index: 11.4 +/- 1.3 kg/m(2)) were included. All participants had global impairment in muscle strength (manual muscle testing: 37.7 +/- 7.7) and PEF (253.3 +/- 60 mL/min) at admission. Muscle weakness was higher in axial than peripheral muscle groups (P < 0.01), with no significant difference between proximal and distal muscles (P > 0.05). Muscle strength at admission was significantly associated with severity of undernourishment (body mass index and albumin) and transaminitis (P < 0.05). At follow-up, musculoskeletal strength and PEF were significantly improved after partial weight recovery (P < 0.01). Conclusions: Extremely undernourished people with anorexia nervosa present a decrease of PEF and musculoskeletal strength predominant on axial muscles. Both are associated with severity of malnutrition and liver damage. Partial recovery was observed after 5 wk of enteral nutrition. (C) 2021 Elsevier Inc. All rights reserved.

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