Journal
NUCLEIC ACIDS RESEARCH
Volume 49, Issue D1, Pages D480-D489Publisher
OXFORD UNIV PRESS
DOI: 10.1093/nar/gkaa1100
Keywords
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Categories
Funding
- National Eye Institute
- National Human Genome Research Institute
- National Heart, Lung, and Blood Institute
- National Institute of Allergy and Infectious Diseases
- National Institute of Diabetes and Digestive and Kidney Diseases
- National Institute of General Medical Sciences
- National Cancer Institute
- National Institute On Aging
- National Institute of Mental Health of the National Institutes of Health [U24HG007822]
- National Human Genome Research Institute [U41HG002273]
- National Institute of General Medical Sciences (National Institutes of Health) [R01GM080646, P20GM103446]
- Biotechnology and Biological Sciences Research Council [BB/T010541/1]
- British Heart Foundation [RG/13/5/30112]
- Open Targets
- Swiss Federal Government through the State Secretariat for Education, Research and Innovation SERI
- European Molecular Biology Laboratory core funds
- National Institutes of Health [U24HG007822]
- BBSRC [BB/M011674/1, BB/T010541/1] Funding Source: UKRI
Ask authors/readers for more resources
The UniProt Knowledgebase aims to provide users with a comprehensive, high-quality set of protein sequences annotated with functional information. Updates over the past two years have increased the number of sequences to approximately 190 million, with new methods to assess proteome completeness and quality. UniProtKB has responded to the COVID-19 pandemic by expertly curating relevant entries and making them rapidly available through a dedicated portal.
The aim of the UniProt Knowledgebase is to provide users with a comprehensive, high-quality and freely accessible set of protein sequences annotated with functional information. In this article, we describe significant updates that we have made over the last two years to the resource. The number of sequences in UniProtKB has risen to approximately 190 million, despite continued work to reduce sequence redundancy at the proteome level. We have adopted new methods of assessing proteome completeness and quality. We continue to extract detailed annotations from the literature to add to reviewed entries and supplement these in unreviewed entries with annotations provided by automated systems such as the newly implemented Association-Rule-Based Annotator (ARBA). We have developed a credit-based publication submission interface to allow the community to contribute publications and annotations to UniProt entries. We describe how UniProtKB responded to the COVID-19 pandemic through expert curation of relevant entries that were rapidly made available to the research community through a dedicated portal. UniProt resources are available under a CC-BY (4.0) license via the web at https://www.uniprot.org/.
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