Distribution of KRASG12C Somatic Mutations across Race, Sex, and Cancer Type

A survey of more than 32,000 cancers in the GENIE registry detected differences in the distribution of KRAS(G12C) mutations in various cancer types and in men and women of different racial groups. With the emerging availability of agents capable of targeting particular mutant alleles (e.g., sotorasib), tumor mutation analysis is increasing in importance for choosing the right treatment.

Automated summary

A survey of over 32,000 cancers in the GENIE registry found differences in distribution of KRAS(G12C) mutations in various cancer types and between men and women of different races. As agents capable of targeting specific mutant alleles like sotorasib become available, tumor mutation analysis is becoming increasingly important in treatment selection.