The neurodevelopmental role of dopaminergic signaling in neurological disorders

Dopamine (DA), a critical neurotransmitter of both the central and peripheral nerve system, plays important roles in a series of biological processes. Dysfunction of dopaminergic signalling may lead to a series of developmental disorders, including attention deficit/hyperactivity disorder, autism and schizophrenia. However, the exact roles of dopaminergic signalling in these diseases are far from fully understood. We analyse the roles of dopaminergic signalling in multiple physiological and pathological processes, focusing on brain development and related disorders. By summarizing current research in this area, we provide guidance for future studies. This review seeks to deepen our understanding of dopaminergic signalling in developmental disorders, which may offer clues for developing more effective therapeutic drugs.

Automated summary

Dopamine, a critical neurotransmitter in both the central and peripheral nervous systems, plays important roles in various biological processes. Dysfunction in dopaminergic signaling may lead to developmental disorders, yet the exact roles in these diseases are not fully understood. Analyzing current research in this area can provide guidance for future studies.