Behavioral consequences of co-administration of MTEP and the COX-2 inhibitor NS398 in mice. Part 2

Our earlier study demonstrated, that antidepressant-like and also cognitive action of MTEP, a metabotmpic glutamate receptor subtype 5 (mGluR5) antagonist, was influenced by cyclooxygenase-2 (COX-2) inhibition in mice. We detected a decrease in the mGluR7 protein level in the hippocampus (HC) of mice co-treated chronically with MTEP and NS398 (a COX-2 inhibitor). We found both antidepressant-like effects and cognitive to be associated with mGlu7 receptor-mediated mechanisms.

Automated summary

Our study showed that the effects of MTEP, a mGluR5 antagonist, on antidepressant-like and cognitive actions were influenced by COX-2 inhibition in mice. Chronic co-treatment with MTEP and NS398 led to a decrease in mGluR7 protein levels in the hippocampus, with both effects being associated with mGlu7 receptor-mediated mechanisms.