4.4 Article

Muscarinic receptor signaling in the amygdala is required for conditioned taste aversion

Journal

NEUROSCIENCE LETTERS
Volume 740, Issue -, Pages -

Publisher

ELSEVIER IRELAND LTD
DOI: 10.1016/j.neulet.2020.135466

Keywords

Acetylcholine; Amygdala; Conditioned taste aversion; Muscarinic receptors; Learning; Retrieval

Categories

Funding

  1. Programa de apoyo a proyectos de investigacion e inovacion tecnologica (PAPIIT) of the Direccion general de asuntos del personal academico (DGAPA) [IA206019, IN224019]

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The sense of taste provides information regarding the nutrient content, safety or potential toxicity of an edible through a combination of innate and learned taste preferences. Recent evidence suggests a role of cholinergic muscarinic signaling in the amygdala for the learning and storage of emotional memories, particularly in conditioned taste aversion.
The sense of taste provides information regarding the nutrient content, safety or potential toxicity of an edible. This is accomplished via a combination of innate and learned taste preferences. In conditioned taste aversion (CTA), rats learn to avoid ingesting a taste that has previously been paired with gastric malaise. Recent evidence points to a role of cholinergic muscarinic signaling in the amygdala for the learning and storage of emotional memories. The present study tested the participation of muscarinic receptors in the amygdala during the formation of CTA by infusing the non-specific antagonist scopolamine into the basolateral or central subnuclei before or after conditioning, as well as before retrieval. Our data show that regardless of the site of infusion, preconditioning administration of scopolamine impaired CTA acquisition whereas post-conditioning infusion did not affect its storage. Also, infusions into the basolateral but not in the central amygdala before retrieval test partially reduced the expression of CTA. Our results indicate that muscarinic receptors activity is required for acquisition but not consolidation of CTA. In addition, our data add to recent evidence pointing to a role of cholinergic signaling in peri-hippocampal structures in the process of memory retrieval.

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