Journal
NEUROSCIENCE LETTERS
Volume 744, Issue -, Pages -Publisher
ELSEVIER IRELAND LTD
DOI: 10.1016/j.neulet.2020.135562
Keywords
Mrgprs; Signaling pathways; Polymorphism
Categories
Funding
- US National Institutes of Health [NS087088, HL141269]
- Pfizer Aspire Dermatology Award
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Mas-related G protein-coupled receptors (Mrgprs) are a family of receptors implicated in various human diseases. Understanding their signal transduction pathways and polymorphisms is crucial for therapeutic efforts, offering insights into new drug candidates, existing drug response variations, and disease susceptibility differences.
Mas-related G protein-coupled receptors (Mrgprs) are a family of receptors implicated in a diverse array of human diseases. Since their discovery in 2001, great progress has been made in determining their relation to human disease. Vital for Mrgprs therapeutic efforts across all disease disciplines is a thorough understanding of Mrgprs signal transduction pathways and polymorphisms, as these offer insights into new drug candidates, existing discrepancies in drug response, and differences in disease susceptibility. In this review, we discuss the current state of knowledge regarding Mrgprs signaling pathways and polymorphisms.
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