Journal
NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS
Volume 120, Issue -, Pages 16-27Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.neubiorev.2020.11.007
Keywords
Dementia; Alzheimer's disease; Cognition; White matter hyperintensities; Cerebral small vessel disease; Meta-analysis; Dose-response
Categories
Funding
- National Key R&D Program of China [2018YFC1314702]
- Shanghai Municipal Science and Technology Major Project [2018SHZDZX01]
- ZJLab
- Shanghai Center for Brain Science and Brain-Inspired Technology
- Tianqiao and Chrissy Chen Institute
- State Key Laboratory of Neurobiology and Frontiers Center for Brain Science of Ministry of Education, Fudan University
Ask authors/readers for more resources
The presence of white matter hyperintensities (WMH) is linked to an increased risk of cognitive impairment and dementia, including Alzheimer's disease and vascular dementia. Higher grade WMH and progressive increases in WMH volume or severity are associated with greater risks of dementia. These findings suggest that WMH could serve as a neuroimaging indicator of dementia.
Background: White matter hyperintensities of presumed vascular origin (WMH) are one of the imaging features of cerebral small vessel disease. Controversies persist about the effects of WMH on cognitive dysfunction. This meta analysis aimed to identify the associations of WMH with risks of cognitive impairment and dementia. Methods: We searched PubMed, EMBASE and Cochrane Library for prospective studies. Primary analyses of cognitive dysfunction and sub-analyses of specific outcomes and study characteristics were conducted using random-effect models. Results: Thirty-six prospective studies with 19,040 participants were included. WMH at baseline conferred a 14 % elevated risk of cognitive impairment and all-cause dementia (ACD). WMH also conferred 25 % elevated risk of Alzheimer's disease and 73 % elevated risk of vascular dementia. Risk effects of high-grade WMH and continually increasing WMH (in volume or severity) on ACD were revealed. Periventricular WMH conferred a 1.51-fold excess risk for dementia. Conclusions: WMH were associated with increased risk of cognitive dysfunction and could become a neuroimaging indicator of dementia.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available