4.7 Review

Four Core Genotypes and XY mouse models: Update on impact on SABV research

Related references

Note: Only part of the references are listed.
Article Neurosciences

Sex differences in kappa opioid receptor antinociception is influenced by the number of X chromosomes in mouse

Anna M. W. Taylor et al.

Summary: KOR agonists are effective in producing analgesia and are considered promising for managing chronic pain and itch. Sex differences have been observed in the KOR system, with females showing lower analgesic response than males, primarily influenced by the number of X chromosomes and the expression of X genes.

JOURNAL OF NEUROSCIENCE RESEARCH (2022)

Article Behavioral Sciences

Sex chromosome complement affects multiple aspects of reversal-learning task performance in mice

Shawn M. Aarde et al.

Summary: The study found that male mice with XY sex chromosome complement exhibited a higher overall error rate compared to female mice with XX sex chromosome complement during a reversal-learning task. XY mice showed more perseverative errors during the task, shorter prepotent-response latencies, and more frequent failures to sustain the observing response compared to XX mice. This suggests that sex-chromosome complement influences response selection in cognitive processes relevant to psychiatric/neurodevelopmental disorders and syndromes associated with sex-chromosome aneuploidies.

GENES BRAIN AND BEHAVIOR (2021)

Article Behavioral Sciences

Sex chromosome complement influences vulnerability to cocaine in mice

Mariangela Martini et al.

HORMONES AND BEHAVIOR (2020)

Article Medicine, Research & Experimental

X chromosome dosage of histone demethylase KDWISC determines sex differences in adiposity

Jenny C. Link et al.

JOURNAL OF CLINICAL INVESTIGATION (2020)

Article Cell Biology

A second X chromosome contributes to resilience in a mouse model of Alzheimer's disease

Emily J. Davis et al.

SCIENCE TRANSLATIONAL MEDICINE (2020)

Article Endocrinology & Metabolism

Hypothalamic oestrogen receptor alpha establishes a sexually dimorphic regulatory node of energy expenditure

J. Edward van Veen et al.

NATURE METABOLISM (2020)

Article Multidisciplinary Sciences

Sex Differences in Mouse Popliteal Lymph Nodes

Riva Dill-Garlow et al.

SCIENTIFIC REPORTS (2019)

Article Multidisciplinary Sciences

XX sex chromosome complement promotes atherosclerosis in mice

Yasir AlSiraj et al.

NATURE COMMUNICATIONS (2019)

Article Medicine, Research & Experimental

The X-linked histone demethylase Kdm6a in CD4+ T lymphocytes modulates autoimmunity

Yuichiro Itoh et al.

JOURNAL OF CLINICAL INVESTIGATION (2019)

Article Behavioral Sciences

Reversal Learning Performance in the XY* Mouse Model of Klinefelter and Turner Syndromes

Shawn M. Aarde et al.

FRONTIERS IN BEHAVIORAL NEUROSCIENCE (2019)

Editorial Material Cell Biology

Female XX sex chromosomes increase survival and extend lifespan in aging mice

Emily J. Davis et al.

AGING CELL (2019)

Article Multidisciplinary Sciences

Parent-of-origin differences in DNA methylation of X chromosome genes in T lymphocytes

Lisa C. Golden et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2019)

Letter Critical Care Medicine

The Y Chromosome Plays a Protective Role in Experimental Hypoxic Pulmonary Hypertension

Soban Umar et al.

AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE (2018)

Article Endocrinology & Metabolism

Hormonal and genetic factors interact to control aromatase expression in the developing brain

C. D. Cisternas et al.

JOURNAL OF NEUROENDOCRINOLOGY (2018)

Article Neurosciences

Impact of X/Y genes and sex hormones on mouse neuroanatomy

Dulcie A. Vousden et al.

NEUROIMAGE (2018)

Article Multidisciplinary Sciences

X chromosome protects against bladder cancer in females via a KDM6A-dependent epigenetic mechanism

Satoshi Kaneko et al.

SCIENCE ADVANCES (2018)

Article Hematology

Sex Chromosome Complement Defines Diffuse Versus Focal Angiotensin II-Induced Aortic Pathology

Yasir Alsiraj et al.

ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY (2018)

Review Developmental Biology

Programming of the reproductive axis by hormonal and genetic manipulation in mice

Susana Beatriz Rulli et al.

REPRODUCTION (2018)

Review Neurosciences

The Importance of Studying Sex Differences in Disease: The Example of Multiple Sclerosis

Lisa C. Golden et al.

JOURNAL OF NEUROSCIENCE RESEARCH (2017)

Review Neurosciences

A General Theory of Sexual Differentiation

Arthur P. Arnold

JOURNAL OF NEUROSCIENCE RESEARCH (2017)

Article Veterinary Sciences

Rat Genome and Model Resources

Mary Shimoyama et al.

ILAR JOURNAL (2017)

Article Cell Biology

Sex chromosome complement involvement in angiotensin receptor sexual dimorphism

Florencia M. Dadam et al.

MOLECULAR AND CELLULAR ENDOCRINOLOGY (2017)

Article Multidisciplinary Sciences

Landscape of X chromosome inactivation across human tissues

Taru Tukiainen et al.

NATURE (2017)

Review Genetics & Heredity

Vertebrate sex determination: evolutionary plasticity of a fundamental switch

Blanche Capel

NATURE REVIEWS GENETICS (2017)

Editorial Material Multidisciplinary Sciences

Y chromosome's roles in sex differences in disease

Arthur P. Arnold

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2017)

Review Hematology

Sex Hormones and Sex Chromosomes Cause Sex Differences in the Development of Cardiovascular Diseases

Arthur P. Arnold et al.

ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY (2017)

Article Biotechnology & Applied Microbiology

Diet, gonadal sex, and sex chromosome complement influence white adipose tissue miRNA expression

Jenny C. Link et al.

BMC GENOMICS (2017)

Article Cell Biology

Stroke sensitivity in the aged: sex chromosome complement vs. gonadal hormones

Louise D. McCullough et al.

AGING-US (2016)

Editorial Material Cell Biology

A RATional choice for translational research?

Tim Aitman et al.

DISEASE MODELS & MECHANISMS (2016)

Review Biology

The importance of having two X chromosomes

Arthur P. Arnold et al.

PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES (2016)

Review Cell Biology

Dosage compensation of the sex chromosomes and autosomes

Christine M. Disteche

SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY (2016)

Review Immunology

Pregnancy and multiple sclerosis: from molecular mechanisms to clinical application

Stefan M. Gold et al.

SEMINARS IN IMMUNOPATHOLOGY (2016)

Article Endocrinology & Metabolism

Evaluating sex as a biological variable in preclinical research: the devil in the details

Cara Tannenbaum et al.

BIOLOGY OF SEX DIFFERENCES (2016)

Review Genetics & Heredity

The Biology and Evolution of Mammalian Y Chromosomes

Jennifer F. Hughes et al.

ANNUAL REVIEW OF GENETICS, VOL 49 (2015)

Article Hematology

Increased High-Density Lipoprotein Cholesterol Levels in Mice With XX Versus XY Sex Chromosomes

Jenny C. Link et al.

ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY (2015)

Article Endocrinology & Metabolism

Number of X-chromosome genes influences social behavior and vasopressin gene expression in mice

Kimberly H. Cox et al.

PSYCHONEUROENDOCRINOLOGY (2015)

Article Genetics & Heredity

Escape from X Inactivation Varies in Mouse Tissues

Joel B. Berletch et al.

PLOS GENETICS (2015)

Article Endocrinology & Metabolism

Neural growth hormone: regional regulation by estradiol and/or sex chromosome complement in male and female mice

Kayla M. Quinnies et al.

BIOLOGY OF SEX DIFFERENCES (2015)

Article Endocrinology & Metabolism

Sex differences in ischemic stroke sensitivity are influenced by gonadal hormones, not by sex chromosome complement

Bharti Manwani et al.

JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM (2015)

Article Cardiac & Cardiovascular Systems

Preliminary Evidence for Aortopathy and an X-Linked Parent-of-Origin Effect on Aortic Valve Malformation in a Mouse Model of Turner Syndrome

Robert B. Hinton et al.

JOURNAL OF CARDIOVASCULAR DEVELOPMENT AND DISEASE (2015)

Article Physiology

Effect of sex chromosome complement on sodium appetite and Fos-immunoreactivity induced by sodium depletion

Florencia M. Dadam et al.

AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY (2014)

Review Endocrinology & Metabolism

Mouse model systems to study sex chromosome genes and behavior: Relevance to humans

Kimberly H. Cox et al.

FRONTIERS IN NEUROENDOCRINOLOGY (2014)

Article Behavioral Sciences

Sex chromosome complement influences operant responding for a palatable food in mice

E. Seu et al.

GENES BRAIN AND BEHAVIOR (2014)

Article Multidisciplinary Sciences

XY sex chromosome complement, compared with XX, in the CNS confers greater neurodegeneration during experimental autoimmune encephalomyelitis

Sienmi Du et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2014)

Article Endocrinology & Metabolism

Neural Growth Hormone Implicated in Body Weight Sex Differences

Paul J. Bonthuis et al.

ENDOCRINOLOGY (2013)

Article Endocrinology & Metabolism

Gonadal- and Sex-Chromosome-Dependent Sex Differences in the Circadian System

Dika A. Kuljis et al.

ENDOCRINOLOGY (2013)

Article Endocrinology & Metabolism

X and Y Chromosome Complement Influence Adiposity and Metabolism in Mice

Xuqi Chen et al.

ENDOCRINOLOGY (2013)

Article Behavioral Sciences

Sexual differentiation in the developing mouse brain: contributions of sex chromosome genes

J. T. Wolstenholme et al.

GENES BRAIN AND BEHAVIOR (2013)

Article Neurosciences

SEX CHROMOSOME COMPLEMENT INFLUENCES FUNCTIONAL CALLOSAL MYELINATION

S. Moore et al.

NEUROSCIENCE (2013)

Article Multidisciplinary Sciences

Sex Chromosomes Regulate Nighttime Sleep Propensity during Recovery from Sleep Loss in Mice

J. Christopher Ehlen et al.

PLOS ONE (2013)

Article Endocrinology & Metabolism

Sex chromosome complement regulates expression of mood-related genes

Marianne L. Seney et al.

BIOLOGY OF SEX DIFFERENCES (2013)

Article Rheumatology

The XX sex chromosome complement in mice is associated with increased spontaneous lupus compared with XY

Manda V. Sasidhar et al.

ANNALS OF THE RHEUMATIC DISEASES (2012)

Review Endocrinology & Metabolism

Neuroprotective effects of estrogens and androgens in CNS inflammation and neurodegeneration

Rory D. Spence et al.

FRONTIERS IN NEUROENDOCRINOLOGY (2012)

Article Behavioral Sciences

X-chromosome dosage affects male sexual behavior

Paul J. Bonthuis et al.

HORMONES AND BEHAVIOR (2012)

Article Endocrinology & Metabolism

Sex Differences in Social Investigation: Effects of Androgen Receptors, Hormones and Test Partner

L. D. Tejada et al.

JOURNAL OF NEUROENDOCRINOLOGY (2012)

Review Genetics & Heredity

The end of gonad-centric sex determination in mammals

Arthur P. Arnold

TRENDS IN GENETICS (2012)

Article Genetics & Heredity

The Number of X Chromosomes Causes Sex Differences in Adiposity in Mice

Xuqi Chen et al.

PLOS GENETICS (2012)

Article Peripheral Vascular Disease

Sex Chromosome Complement Contributes to Sex Differences in Bradycardic Baroreflex Response

Ximena E. Caeiro et al.

HYPERTENSION (2011)

Review Neurosciences

Reframing sexual differentiation of the brain

Margaret M. McCarthy et al.

NATURE NEUROSCIENCE (2011)

Article Endocrinology & Metabolism

Sex chromosome complement contributes to sex differences in coxsackievirus B3 but not influenza A virus pathogenesis

Dionne P Robinson et al.

Biology of Sex Differences (2011)

Article Endocrinology & Metabolism

Male 41, XXY* Mice as a Model for Klinefelter Syndrome: Hyperactivation of Leydig Cells

Joachim Wistuba et al.

ENDOCRINOLOGY (2010)

Article Peripheral Vascular Disease

Sex Chromosome Effects Unmasked in Angiotensin II-Induced Hypertension

Hong Ji et al.

HYPERTENSION (2010)

Article Neurosciences

Dissociation of Genetic and Hormonal Influences on Sex Differences in Alcoholism-Related Behaviors

Jacqueline M. Barker et al.

JOURNAL OF NEUROSCIENCE (2010)

Article Endocrinology & Metabolism

Sex differences in hypothalamic astrocyte response to estradiol stimulation

John Kuo et al.

Biology of Sex Differences (2010)

Article Endocrinology & Metabolism

Elucidating the Role of Gonadal Hormones in Sexually Dimorphic Gene Coexpression Networks

Atila van Nas et al.

ENDOCRINOLOGY (2009)

Article Neurosciences

X chromosome number causes sex differences in gene expression in adult mouse striatum

Xuqi Chen et al.

EUROPEAN JOURNAL OF NEUROSCIENCE (2009)

Review Endocrinology & Metabolism

What does the four core genotypes mouse model tell us about sex differences in the brain and other tissues?

Arthur P. Arnold et al.

FRONTIERS IN NEUROENDOCRINOLOGY (2009)

Article Psychology, Biological

Impaired recognition memory in male mice with a supernumerary X chromosome

Lars Lewejohann et al.

PHYSIOLOGY & BEHAVIOR (2009)

Article Behavioral Sciences

Sex chromosome complement affects social interactions in mice

Anika A. McPhie-Lalmansingh et al.

HORMONES AND BEHAVIOR (2008)

Article Immunology

A role for sex chromosome complement in the female bias in autoimmune disease

Deborah L. Smith-Bouvier et al.

JOURNAL OF EXPERIMENTAL MEDICINE (2008)

Article Clinical Neurology

Sex Chromosome Complement Affects Nociception and Analgesia in Newborn Mice

Laura Gioiosa et al.

JOURNAL OF PAIN (2008)

Article Neurosciences

Sex chromosome coemplement regulates habit formation

Jennifer J. Quinn et al.

NATURE NEUROSCIENCE (2007)

Article Biochemistry & Molecular Biology

Commonalities in compensation

JA Birchler et al.

BIOESSAYS (2006)

Review Biochemistry & Molecular Biology

Sex chromosome specialization and degeneration in mammals

JAM Graves

Article Endocrinology & Metabolism

A Yin-Yang effect between sex chromosome complement and sex hormones on the immune response

KM Palaszynski et al.

ENDOCRINOLOGY (2005)

Article Endocrinology & Metabolism

Sexually dimorphic expression of co-repressor Sin3A in mouse kidneys

J Xu et al.

ENDOCRINE RESEARCH (2005)

Article Developmental Biology

Analysis of sex differences in EGC imprinting

G Durcova-Hills et al.

DEVELOPMENTAL BIOLOGY (2004)

Article Reproductive Biology

Effects of sex chromosome dosage on placental size in mice

H Ishikawa et al.

BIOLOGY OF REPRODUCTION (2003)

Article Neurosciences

Sex chromosome genes directly affect brain sexual differentiation

LL Carruth et al.

NATURE NEUROSCIENCE (2002)

Article Biochemistry & Molecular Biology

Sex differences in sex chromosome gene expression in mouse brain

J Xu et al.

HUMAN MOLECULAR GENETICS (2002)